Pediatric Heart Network - Utah Center

项目总结/摘要 自年成立以来，作为NHLBI儿科心脏网络（PHN）中最富有成效的核心中心之一， 2001年，犹他州中心支持PHN的使命，以改善先天性心脏病患者的健康结果。 心脏病（CHD）和儿童获得性心脏病，同时培训新的研究人员，并提供 在开展高影响力、符合伦理的临床研究期间，为家庭提供支持和宣传。研究 在此期间，团队始终保持一致，为PHN科学做出了重大贡献 发现和行政活动。犹他州的调查人员和 持续的强有力的机构支持将使领导层能够不间断地顺利过渡到下一个 奖周期。研究受试者的招募和保留一直是所有中心中最高的，因为 犹他州团队的承诺，全天候覆盖每一位符合条件的患者， 作为唯一一家服务于广泛集水区的心脏中心，现场审计有 对犹他州中心数据的高质量、完整性和及时录入表示赞赏。今后， 犹他州中心在新的PHN灵活平台下具有持续成功的独特优势， 研究可由各种来源供资。犹他州是目前仅有的两个核心中心之一， NHLBI Bench-to-Bassinet（B2B）计划的所有三个联盟，并开发了犹他州综合 科学委员会将B2B研究人员与NIH新生儿研究和孕产妇研究的研究人员联合起来， 胎儿医学单位网络沿着与其他专家临床/翻译心血管研究人员，以促进 团队科学。该委员会指导一个协作的、多学科的研究团队， 校外资助犹他州参与了许多多中心数据库和登记研究，并将加快 这些登记册与PHN项目的接口。犹他州的研究人员目前正在领导PHN试点研究， 初步数据，以提出更大规模的临床试验。犹他州中心在制药资助的药物 犹他州CCTS和临床试验办公室在促进行业发展方面有着成功的历史 资助的审判。犹他州致力于培养下一代的医学科学家， 培训计划与广泛的教师发展资源和合作，在许多相关的NIH 网络. PHN犹他州中心的目标是：1）继续模范性能和领导，利用 在临床试验管理中吸取的经验教训，以促进PHN过渡到新的灵活平台，2） 通过团队科学基础设施利用最先进的科学能力来开发和扩展 PHN的科学资源和生产力，以及3）为下一代提供培训和指导 推动CHD研究。犹他州中心成功领导的记录， 最先进的设施、大的集水区以及广泛的研究和指导基础设施将 推进PHN使命，并允许新的发现来改善这一人群的结果。

PROJECT SUMMARY/ABSTRACT As one of the most productive Core Centers in the NHLBI Pediatric Heart Network (PHN) since its inception in 2001, the Utah Center supported the PHN's mission to improve health outcomes in individuals with congenital heart disease (CHD) and children with acquired heart disease while training new investigators and providing support and advocacy for families during the conduct of high-impact, ethical clinical research. The research team has remained consistent throughout this time, making substantial contributions to PHN scientific discoveries and administrative activities. Long-standing collaboration among the Utah investigators and continued strong institutional support will allow uninterrupted leadership and seamless transition into the next award cycle. Recruitment and retention of study subjects has been among the highest of all Centers due to the commitment of the Utah team, around-the-clock coverage to approach every eligible patient, and access to large patient populations as the only Heart Center serving a wide catchment area. Site audits have commended the high quality, completeness, and timely entry of data from the Utah Center. Moving forward, the Utah Center is uniquely positioned for continued success under the new PHN flexible platform where studies may be funded by a variety of sources. Utah is currently one of only two Core Centers participating in all three consortia of the NHLBI Bench-to-Bassinet (B2B) program, and developed the Utah Integrative Science Committee to join B2B investigators with researchers from the NIH Neonatal Research and Maternal- Fetal Medicine Units Networks along with other expert clinical/translational cardiovascular researchers to foster team science. This committee guides a collaborative, multi-disciplinary research team that can strengthen bids for extramural funding. Utah participates in numerous multicenter databases and registries and will expedite the interface of these registries with PHN projects. Utah investigators currently lead PHN pilot studies obtaining preliminary data to propose larger clinical trials. The Utah Center has performed well in pharma-funded drug and device trials, and the Utah CCTS and Clinical Trials Office have a successful history of facilitating industry funded trials. Utah is committed to the next generation of physician-scientists and is ideally positioned to lead training initiatives with extensive faculty development resources and collaboration in numerous, relevant NIH Networks. The aims of the PHN Utah Center are: 1) continue exemplary performance and leadership, utilizing lessons learned in clinical trials administration to facilitate the PHN transition to a new flexible platform, 2) leverage state-of-the-art scientific capabilities through team science infrastructure to develop and expand the scientific resources and productivity of the PHN, and 3) provide training and mentoring for the next generation of physician-scientists to advance CHD research. The Utah Center's track record of successful leadership, state-of-the-art facilities, large catchment area, and extensive research and mentoring infrastructure will advance the PHN mission and allow new discoveries to improve outcomes in this population.