UCLA Clinical and Translational Science Institute

摘要/摘要 加州大学洛杉矶分校临床和转化科学研究所是加州大学的研究伙伴关系 洛杉矶、锡达斯-西奈医学中心、查尔斯·R·德鲁医科大学和海港- 加州大学洛杉矶分校医学中心/伦德奎斯特生物医学创新研究所。我们的使命是将生物医学 创新以满足洛杉矶最大的健康需求，洛杉矶是一个种族和经济多元化的城市 拥有1000多万人口的大都市。在过去的10年里，我们建立了强大的研究基础设施，以 支持我们的使命。在与社区的合作中，我们在打击主要的 可预防的残疾和死亡原因。支持这些进步的是精简的监管基础设施。 我们建立了科学审查，将学习激活时间减少了42%，并实现了100%的合规性 在ClinicalTrials.gov上。随着我们进入下一个十年，我们正在通过扩大 与我们的机构中心合作伙伴整合，并扩大社区内以及与 卫生专业以外的调查人员。因为公平、多样性和包容性(EDI)是 根据我们CTSI的原则，我们已经开始了一项包容性的科学倡议，由我们的EDI高级研究员领导 主任，以确保我们的研究和培训计划继续遵循这一指导原则。穿过 新的T1-T4研讨会和团队科学培训和机会，我们正在装备我们的学员进行 跨翻译领域的多学科团队科学。我们正在系统地评估我们的CTSI 结果和总体影响。加州大学洛杉矶分校CTSI有五个具体目标：1)加强教育和培训，以 准备和扩大翻译员工队伍，2)让利益相关者社区参与多学科 团队科学和传播成功的合作模式，3)融合特殊人群， 包括那些经历健康差距的人，纳入转化性研究，4)改进方法和 加速高效、高质量、多站点研究的流程，并提供信息学解决方案 以推动高影响力的翻译科学。

SUMMARY/ABSTRACT The UCLA Clinical and Translational Science Institute is a research partnership of the University of California Los Angeles, Cedars-Sinai Medical Center, Charles R. Drew University of Medicine and Science and the Harbor- UCLA Medical Center/ Lundquist Institute for Biomedical Innovation. Our mission is to bring biomedical innovations to bear on the greatest health needs of Los Angeles, an ethnically and economically diverse metropolis of more than 10 million people. In the past 10 years, we have built a robust research infrastructure to support our mission. In partnership with the community, we have made important advances against the leading causes of preventable disability and death. Supporting these advances is a streamlined regulatory infrastructure. We have instituted scientific review, reduced time-to-study-activation by 42%, and achieved 100% compliance with ClinicalTrials.Gov. As we enter our next decade, we are building on our progress by augmenting the integration with our institutional hub partners and broadening collaborations in the community as well as with investigators outside the health professions. Because Equity, Diversity and Inclusion (EDI) is a foundational principle of our CTSI, we have embarked on an Inclusive Science Initiative, led by our EDI Senior Associate Director, to ensure that our research and training programs continue to embrace this guiding principle. Through new T1-T4 seminars and team science trainings and opportunities, we are equipping our trainees to conduct multidisciplinary team science across the translational spectrum. We are systematically evaluating our CTSI outcomes and overall impact. The UCLA CTSI has five specific aims: 1) Enhance education and training to prepare and expand the translational workforce, 2) Engage stakeholder communities in multidisciplinary team science and disseminate successful models of collaboration, 3) Integrate special populations, including those experiencing health disparities, into translational research, 4) Improve methods and processes to accelerate efficient, high-quality, multisite research, and 5) Provide informatics solutions to advance high-impact translational science.