Biostatistics and Data Management Core

项目总结/摘要：生物统计学和数据管理核心 生物统计和数据管理核心将为三个主要项目、试点项目和 实习生核心团队由经验丰富的生物统计学家和其他定量专家组成，具有广泛的多样性 技能，包括创新的统计分析，REDCAP数据库设计和管理，临床试验 监测和报告以及生物信息学。核心在以前已经开发了一个大型基础设施， 资助期间（宾夕法尼亚州立大学TCORS; P50 DA 036107），并与每个项目负责人密切合作。 核心将是整个项目的一个组成部分。其成员将参加定期项目会议 并将通过欢迎步入式讨论和快速周转数据来提供及时和高质量的服务 分析（1-3个工作日）。核心主任还将在每次外部咨询会议上提交进度报告， 董事会会议。核心将采取措施，提高研究的严谨性和可重复性，使用 REDCAP数据库管理系统，确保数据的准确性，每周提供研究进展报告， 并确保在数据收集和分析开始之前有一套明确定义的科学问题， 采用最佳做法和透明的统计方法。总体而言，三个主要项目、试点项目和 职业发展活动测试有关烟草产品及其对成瘾，毒性， 和健康影响。生物统计学核心员工精通烟草研究，共同撰写了 TCORS出版物，并就与烟草有关的具体问题提供统计方法方面的建议。 他们将参加职业提升培训计划，包括指导学生和服务 作为TCORS认证课程的课堂讲师。此外，他们还将担任试点项目的统计顾问 项目，包括提供电力计算，设计问题和结果的统计分析援助。

PROJECT SUMMARY / ABSTRACT: Biostatistics and Data Management Core The Biostatistics and Data Management Core will provide support for the three Main Projects, Pilot Projects and trainees. The Core has a team of experienced biostatisticians and other quantitative experts with a wide diversity of skills, including innovative statistical analysis, REDCAP database design and management, clinical trials monitoring and reporting and bioinformatics. The Core has developed a large infrastructure in the previous funding period (Penn State TCORS; P50 DA036107) and has worked closely with each of the project leaders. The Core will be an integral part of the whole Project. Its members will participate in regular project meetings and will provide timely and high-quality service by welcoming walk-in discussion and by quick turnaround in data analysis (1-3 workdays). The Core Director will also present progress reports at each of the External Advisory Board meetings. The core will take steps to enhance the rigor and reproducibility of the research, using the REDCAP database management system to ensure data accuracy, providing weekly reports of study progress, and ensuring that have a set of clearly defined scientific questions before data collection and analysis begins, using best-practice and transparent statistical methods. Overall, the three Main Projects, Pilot Projects and Career Development activities test hypotheses about tobacco products and their impact on addiction, toxicity and health effects. The biostatistics Core staff have become well versed in tobacco research, have co-authored TCORS publications, and provide advice on statistical approaches as they relate to tobacco-specific issues. They will participate in the Career Enhancement Training Program, including mentoring of students and serving as class instructors in the TCORS-accredited courses. Additionally, they will be statistical consultants to the pilot projects, including providing assistance with power calculations, design issues and statistical analyses of results.