Discovery to Commercialization Program for Substance Abuse Prevention and Treatment (D2C: SAPT)

项目摘要 对物质使用障碍（SUD）的投资严重不足，并继续依赖 同样的方法不起作用。在这份提案中，我们积极寻求支持颠覆性创新， 阻止SUD的上升趋势并刺激进步。这种破坏最有可能来自那些 积极参与治疗和提高SUD的知识。但许多有能力这样做的人并不知道， 或看到发现商业化的价值。我们的首要目标是让更多的基础科学家思考 像企业家一样，并获得他们参与商业化所需的资源， 流程.通过我们提出的任务，我们将开发和提供创业教育， 为基础科学研究人员，赋予他们所需的工具，使他们的发现商业化， 颠覆性创新，推进SUD的预防、诊断和治疗。 药物滥用预防和治疗的发现到商业化计划 (D2C：SAPT）课程将在这5年的资助期间得到系统的开发、实施和评估 期该计划的基石是约翰商学院新的创业证书 霍普金斯大学凯里商学院（目标2）。该计划将利用我们的教学经验 企业家精神的科学家在约翰霍普金斯和定制的南加州大学的研究人员。异步 为证书计划开发的在线模块将广泛分发（目标1），并通过我们的 我们将有意识地建立（目标3）和多样化（目标4）能够支持的社区 将发现转化为市场和影响SUD。 这将是一个专门的计划，为南加州大学的研究人员在所有职业水平的科学家， 以理论框架为基础，并辅之以与企业家有关的专业教育 身份形成和社区建设。D2C：SAPT将包括三个部分：异步模块 包括构思、市场发现、知识产权、监管策略、商业和 金融建模，包括在SUD诊所观察，对话， 与利益相关者，设计和原型设计，以及一个指导的体验式学习组件，最终在一个 球场竞争课程毕业生将有能力申请翻译资金，专利和许可证 知识产权或发射公司。更广泛地说，他们将成为一个大型虚拟社区的一部分， 研究人员和从业人员，并将在改变学术科学家的文化中发挥作用。与 对SUD领域存在的差距、可能的创新类型以及 培训科学家将其发现推向市场所需的过程，该培训计划将 通过促进启动将SUD的临床实践转移到 下一代解决方案。

Project Summary There has been critical underinvestment in Substance Use Disorders (SUDs) and continuing to rely on the same approaches is not working. In this proposal, we actively seek to support disruptive innovations to stem the rising tide of SUDs and stimulate progress. Such disruptions are most likely to come from those actively engaged in treating and advancing knowledge of SUDs. But many in a position to do so are not aware of or see value in discovery commercialization. Our overarching goals are to have more basic scientists think like entrepreneurs and to have access to the resources they need to engage in the commercialization processes. Through our proposed tasks, we will develop and deliver entrepreneurship education that is curated for basic science researchers, empowering them with the tools they need to commercialize their discoveries, disruptively innovate, and advance the prevention, diagnosis, and treatment of SUDs. The Discovery to Commercialization Program for Substance Abuse Prevention and Treatment (D2C: SAPT) curriculum will be systematically developed, implemented, and evaluated during this 5-year grant period. The cornerstone of the proposed initiative is a new Certificate in Entrepreneurship at the Johns Hopkins University Carey Business School (Aim 2). This program will leverage our experience in teaching entrepreneurship to scientists at Johns Hopkins and be customized to SUD researchers. The asynchronous online modules developed for the certificate program will be distributed widely (Aim 1), and through our educational efforts we will intentionally build (Aim 3) and diversify (Aim 4) the community that can support translation of discovery to market and impact SUDs. This will be a specialized program for SUD researchers aimed at scientists at all career levels that is grounded in theoretical frameworks and complemented by professional education related to entrepreneur identity formation and community building. D2C: SAPT will comprise three parts: asynchronous modules consisting of topics in ideation, market discovery, intellectual property, regulatory strategy, business, and financial modeling, an in-person multi-day workshop comprising observations in SUD clinics, conversations with stakeholders, design, and prototyping, and a mentored experiential learning component culminating in a pitch competition. Program graduates will be equipped to apply for translational funding, patents, and to license intellectual property or launch companies. More broadly, they will be part of a large virtual community of researchers and practitioners and will play a role in transforming the culture of academic scientists. With a keen understanding of the gaps that exist in the SUD field, the types of innovations that are possible, and the process needed to train scientists in moving their discoveries to market, this training program will have substantial public health impact by facilitating the launch of projects that move clinical practice in SUD to the next generation of solutions.