Core B - Animal Core

核心B：动物核心摘要 当前计划项目的一个协同方面是所有单独的项目 将在几个常见模型中评估他们的研究问题的某些方面，例如， 心内和胫骨内注射肿瘤细胞。拥有共同的动物模型使我们能够 快速将调查结果从一个项目转换到另一个项目。由于骨骼的独特性质 与软组织相比，许多骨转移模型具有挑战性，需要特殊的 专业知识。在过去的几年中，动物核心为该计划提供了广泛的服务 格兰特循环。在之前的评论中，动物核心杂志的目标是 继续向每个项目的调查人员提供进行研究方面的协助 涉及动物，包括建立独特的动物模型(例如，椎体 植入物，心内和腔内注射，体内和体外肿瘤 成像和各种动物程序。核心已经非常成功地实现了它的 进球，并在评论中一直被评为优秀。要继续完成对 动物核心计划有以下目标： 目标1.创建和评估用于项目的动物模型。除了……之外 常规的动物模型，我们将促进使用独特的骨转移动物模型 研究或其他方面都是具有挑战性的。例如，植入椎骨以创造血管， 腔内注射、心内注射和原位植入将由 动物核心。 目的2.协助动物实验。核心人员将协调和协助或 指导标准化程序的执行，如活体成像、心脏内成像 注射、复方注射、麻醉等。 目标3.为动物成像。核心将协助成像，包括Faxitron射线照片， 生物发光成像、骨密度扫描和CT。 目标4.提供使用动物模型和解释来自这些模型的数据的专业知识 动物。埃文·凯勒博士是董事会认证的兽医肿瘤学家，吉尔·凯勒博士是董事会成员- 注册实验动物兽医，将提供动物模型解释方面的专业知识 视需要而定。 目的5.确保所有动物实验有适当的动物依从性。在……里面 与管理核心合作，我们将确保所有实验都在 适当的机构批准

Core B: Animal Core Summary One of the synergistic aspects of the current Program Project is that all of the individual projects will evaluate some aspect of their research questions in several common models, e.g., intracardiac and intratibial injection of tumor cells. Having common animal models allows us to rapidly translate findings from one project to another project. Due to the unique nature of bone compared to soft tissues, many models of bone metastasis are challenging and require special expertise. The Animal Core has provided extensive service to the Program in the previous grant cycle. The goal of the Animal Core, which has rated Superior, in previous reviews, is to continue to provide investigators of each project with assistance in the conduct of research involving animals including establishment of unique animal models (e.g., vertebral body implants known as vossicles), intracardiac and intratibial injection, in vivo and ex vivo tumor imaging and miscellaneous animal procedures. The core has been very successful achieving its goals and has always rated Superior in reviews. To continue to accomplish support of the Program the Animal Core has the following Aims: Aim 1. Creating and assessing animal models to be used for the projects. In addition to routine animal modeling, we will facilitate use of animal models unique to bone metastasis research or that are challenging. For example, implantation of vertebrae to create vossicles, intratibial injections, intracardiac injections and orthotopic implants will be performed by the Animal Core. Aim 2. Assisting with animal experiments. Core personnel will coordinate and assist or instruct in the performance of standardized procedures such as in vivo imaging, intracardiac injections, compound injections, anesthesia, etc. Aim 3. Imaging animals. The core will assist with imaging including faxitron radiographs, bioluminescent imaging, bone density (DEXA) scanning and CT. Aim 4. Providing expertise in use of animal models and interpretation of data from these animals. Dr. Evan Keller, a Board-certified veterinary oncologist and Dr. Jill Keller, a Board- certified laboratory animal veterinarian, will provide expertise in interpretation of animal models as needed. Aim 5. Ensuring all animal experiments have appropriate animal compliance. In collaboration with Administrative core, we will ensure that all experiments are performed under appropriate institute approval