An integrated multiplexed electrochemical platform for the selective detection of viral protein and RNA to differentiate active HIV-1 infection from vaccine induced seropositivity

区分艾滋病毒感染和疫苗诱导的血清阳性的诊断方法的发展：几年的临床试验表明，一些艾滋病毒疫苗可引起持久（大约15年）的血清学免疫反应，在普通诊断测试中可能与艾滋病毒感染混淆。这种现象被称为疫苗诱导的血清反应性或血清阳性（VISR/VISP）。该项目的总体目标是支持开发新的血清学和核酸检测方法，以高灵敏度和特异性识别HIV感染，同时避免因VISP而导致的假阳性结果。

Development of Diagnostics to Differentiate HIV Infection from Vaccine Induced Seropositivity: Several years of clinical trials have revealed that some HIV vaccines can elicit long-lasting (>15 years) serological immune responses that can be confused with HIV infection in common diagnostic tests. This phenomenon is known as vaccine-induced sero-reactivity or sero-positivity (VISR/VISP). The overarching goal of this program is to support the development of new serological and nucleic acid assays that can identify HIV infection while avoiding false-positive results due to VISP, with high sensitivity and specificity.