RC-ISC

ISC摘要：集成系统核心（ISC）的基本概念是， 在明显的临床问题之前，与年龄相关的活动性和平衡性变化会发生微妙的变化，这是由于 多系统互动变化。ISC提供与年龄相关的最先进的多学科专业知识 通过合作实验室改变活动性，包括1）全身运动和平衡，2） 神经系统结构、功能和能量学，以及3）心肺和肌肉骨骼结构， 功能和能量。这些实验室相互合作，以及与其他胡椒核心 和中心将同步多系统评估引入研究。在本周期内， 国际科学委员会支助了11项试点探索性研究、2个发展项目、23名区域环境中心受训人员（7名 学者）和50多个外部资助的项目（EP），几乎所有这些项目都涉及与其他 胡椒核心，其他皮特中心，其他胡椒中心，和其他机构。 在这次更新中，ISC将与其他Pepper Core合作支持3个PES和2个DP。的ISC 将增加广泛和创新的新资源：1）线粒体的非侵入性体内评估 心、脑、肌肉功能; 2）运动时心肺生理变化; 3）肌肉功能; 结构，神经支配和能量学，包括脊髓生理学; 4）一套经过验证的任务， 双重任务和认知运动接口的评估;和5）可穿戴设备，以测量大脑和 步行时的肌肉活动（NIRS和高密度EMG），以及通过组合的空间导航 加速度计-GPS系统在实验室外。我们的具体目标是： 1.提供尖端的资源和专业知识，同时研究全身以及多个 影响衰老过程中移动性和平衡的系统和生理机制， 在规划、实施和分析过程中。 2.开发和测试新的技术和方法，以解决多系统的差距和需求 评价流动性和平衡性。 3.通过教育和支持Pepper学员的工作，支持OAIC的培训使命 通过工作组、研讨会、“实地考察”和积极参与受训人员的研究项目。 4.与皮特内外的其他核心和中心就OAIC相关活动进行合作。 5.持续监控、评估和沟通核心内部和之间的核心活动 实验室领导，以及与其他胡椒核心，胡椒领导和NIA。 综上所述，ISC自成立以来就形成了匹兹堡胡椒的核心， 有助于创造和传播新知识和新方法，以预防和治疗年龄- 与流动性和平衡有关的问题。

ISC Summary/Abstract: The fundamental concepts underlying the Integrative Systems Core (ISC) are that age-related alterations in mobility and balance develop subtly, prior to overt clinical problems, and are due to multi-system interacting changes. The ISC provides state-of-the-art multidisciplinary expertise on age-related change in mobility via collaborating laboratories encompassing 1) whole-body movement and balance, 2) nervous system structure, function and energetics, and 3) cardiopulmonary and musculoskeletal structure, function and energetics. These laboratories collaborate with each other, as well as with other Pepper Cores and Centers to bring simultaneous multisystem evaluation to research studies. During the current cycle, the ISC supported 11 pilot exploratory studies (PES), 2 developmental projects (DPs), 23 REC trainees (7 scholars), and over 50 externally funded projects (EP), virtually all of which involved collaboration with other Pepper Cores, other Pitt Centers, other Pepper Centers, and other institutions. In this renewal, the ISC will support 3 PES and 2 DPs in collaboration with other Pepper Cores. The ISC will add extensive and innovative new resources for: 1) non-invasive in-vivo assessment of mitochondrial function in heart, brain and muscle; 2) cardio-pulmonary physiological changes during exercise; 3) muscle structure, innervation and energetics including spinal cord physiology; 4) a validated set of tasks for detailed assessment of dual tasks and the cognitive-motor interface; and 5) wearable devices to measure cerebral and muscle activity while walking (NIRS and high-density EMG), as well as in-place spatial navigation via combined accelerometry-GPS systems outside the laboratory. Our specific aims are: 1. Provide cutting-edge resources and expertise to concurrently study both whole-body as well as multiple systems and physiologic mechanisms affecting mobility and balance during aging, both during study planning as well as during implementation and analysis. 2. Develop and test novel techniques and approaches to address gaps and needs for multi-system evaluation of mobility and balance. 3. Support the training mission of the OAIC by educating and supporting the work of Pepper trainees through workgroups, seminars, “field trips” and active involvement in trainee research projects. 4. Collaborate with other Cores and Centers in and outside Pitt on OAIC-related activities. 5. Continuously monitor, evaluate and communicate about Core activities both within and among Core laboratory leaders, as well as with other Pepper Cores, Pepper leadership and NIA. In summary, the ISC has formed the heart of the Pittsburgh Pepper since its inception and has been instrumental in creating and disseminating new knowledge and new approaches to prevent and treat age- related problems with mobility and balance.