Quantitative Bioscience Core

项目总结/摘要 核心1：定量生物科学核心 定量生物科学核心的主要目标是为生物统计学提供集中服务， 生物信息学的需求。该核心将与所有三个项目和HPM核心密切合作， 提供实验设计和多层次的组学数据分析，以深入了解 与腺瘤进展和恶性转化相关的微环境改变。芯会 为所有动物和临床研究提供质量控制，为多组学数据提供最先进的管道和方法 分析，并开发和评估新的方法，用于整合单细胞和空间转录组学分析。

PROJECT SUMMARY/ABSTRACT Core 1: Quantitative Bioscience Core The main goal of the Quantitative Bioscience Core is to provide a centralized service for biostatistics and bioinformatics needs of the program. The core will work closely with all three projects and the HPM Core to provide experimental design and multi-level omics data analysis to enable in-depth understanding of microenvironment alterations associated with adenoma progression and malignant transformation. The core will provide quality control for all animal and clinical studies, cutting edge pipelines and methods for multi-omics data analysis, and develop and evaluate novel methods for integrative single-cell and spatial transcriptomics analysis.