University of Wisconsin Institute for Clinical and Translational Research

联系PD/PI：Brasier，Allan 总体摘要。此申请是临床和转化科学奖的延续 （CTSA）在威斯康星大学麦迪逊分校（UW）临床和转化研究所（ICTR）。 通过与合作学校和我们的“发言”组织，马什菲尔德诊所有意义的合作 研究院，我们扩大支持和创新，以加速临床和转化研究（CTR） 穿过我们的枢纽在过去的资助期间，我们的KL 2学者成功地竞争了1.31亿美元， 校外资助我们的循证CTR导师制在51个CTSA中培训了501名主辅导员。我们 参与了威斯康星州90%的县的区域网络。最近，卢旺达问题国际法庭领导了多个有影响力的中期 课程更正使我们的学生，工作人员和科学家能够有效地解决卫生不公平现象 受到COVID-19大流行的影响。在用户需求评估、SWOT分析和机构范围内 战略规划我们开发了一个创新记分卡，作为一个路线图， 改进，以应对在进行高效、严格和参与的CTR方面持续存在的挑战。我们 该应用程序可实现5个有影响力的目标，这些目标与我们的创新记分卡中的目标一致，每次测试 明确的假设这些目标是：1）提高CTR员工的技能、效率和弹性， 有效地参与合作减少风险的多学科方法。我们测试一种生态系统方法， 学员弹性，并建议提高临床研究，指导和团队的学术认可 科学2)使用双向社区参与和包容性培训来增加参与 在CTR中，历史上代表性不足的群体，导致改善健康公平。我们将测试 纳入创新的利益攸关方参与、传播和实施，以及团队科学 这些方法提高了卫生系统和社区干预措施的忠实性和可持续性。第三章 采用有意识的系统级变革战略，打破多样性、公平性和包容性方面的障碍 从而形成“包容性卓越”的校园文化。我们测试基于证据的劳动力干预措施 翻译的多样性和能力，使历史上代表性不足的群体参与CTR。4)支持 一个可持续的信息学生态系统，将数据转化为知识， 并促进CTR的严谨性和可重复性。我们将提供和支持 安全的数据共享、可互操作的系统、以疾病为重点的登记册和训练有素的信息专家， 先进的数据驱动CTR。5)为临床研究整合“从概念到结论”的支持模式 参与UW健康区域和国家网络。我们将CTR的支持整合到UW Health中。我们 将测试临床试验者的实践社区是否会提高我们的CTR能力。卢旺达问题国际法庭的广泛 覆盖面广、经验丰富的领导层、高效的基础设施和伙伴关系将使我们能够取得进展 翻译科学作为一门严谨的学科，在CTR中提供颠覆性的创新。 项目摘要/摘要第271页 联系PD/PI：Brasier，Allan 整体

Contact PD/PI: Brasier, Allan OVERALL ABSTRACT. This application is for renewal for the Clinical and Translational Science Award (CTSA) at the University of Wisconsin-Madison (UW) Institute for Clinical and Translational Research (ICTR). Through meaningful collaborations with partnering schools and our “spoke” organization, Marshfield Clinic Research Institute, we expand support and innovation to accelerate clinical and translational research (CTR) across our Hub. Over the past funding period, our KL2 scholars have successfully competed for $131M in extramural funding. Our evidence-based CTR mentorship trained 501 master facilitators in 51 CTSAs. We engaged regional networks in 90% of the counties in Wisconsin. Recently, ICTR led multiple impactful mid- course corrections enabling our students, staff, and scientists to effectively address health inequities revealed by the COVID-19 pandemic. Building on user needs assessments, SWOT analyses, and institute-wide strategic planning we developed an Innovation Scorecard that serves as a roadmap to use continuous improvement to address ongoing challenges in conducting efficient, rigorous, and engaged CTR. Our application addresses 5 impactful Aims aligned with objectives in our Innovation Scorecard, each testing explicit hypotheses. These Aims are: 1) Expand skills, efficacy, and resiliency of the CTR workforce to engage effectively in multidisciplinary approaches to CTR. We test an eco-systems approach to promote trainee resiliency, and propose to enhance academic recognition of clinical research, mentorship, and team science. 2) Use bidirectional community engagement and inclusion training for increased involvement of historically underrepresented groups in CTR leading to improved health equity. We will test whether incorporating innovative stakeholder engagement, dissemination and implementation, and team science approaches improve the fidelity and sustainability of interventions in health systems and communities. 3) Employ intentional, systems-level change strategies to break barriers in diversity, equity, and inclusion leading to a campus culture of “inclusive excellence.” We test evidence-based interventions on workforce diversity and ability of translational reams to engage historically underrepresented groups in CTR. 4) Support a sustainable informatics ecosystem to transform data to knowledge, enhance integration of research into health care delivery, and promote rigor and reproducibility in CTR. We will provide and support secure data sharing, interoperable systems, disease-focused registries and well-trained informaticians to advance data-driven CTR. 5) Integrate a “concept-to-closure” support model for clinical research engaging UW Health regional and national networks. We integrate support for CTR within UW Health. We will test whether communities of practice for clinical trialists will enhance our CTR capacity. ICTR’s broad reach, experienced leadership, high-functioning infrastructure, and partnerships will enable us to advance translational science as a rigorous discipline, providing disruptive innovations in CTR. Project Summary/Abstract Page 271 Contact PD/PI: Brasier, Allan OVERALL