The Broad-LMM-Color Genome Center for All of Us

我们所有人的研究计划(AoURP)需要一个强大、准确和全面的CLIA 经过验证的样品接收流程，每月可高质量处理约17,000个样品。 到目前为止，Samples Lab已经接收、访问和存储了200多万个样本(图2)，并且 在大型国家生物库中进行了大规模测试。为了确保高质量的高规模，我们的工艺 利用高度优化的自动化和完整的LIMS跟踪来确保保管链并应用各种 对所有进货样品进行质量控制(QC)分析。我们使用相同的流程来接收这两种产品的样品 基因分型和测序。这种简化的方法-即，在一个单独的 CLIA实验室环境-降低跨实验室样本身份检查的成本，实现无缝 测序数据与基因数据的交叉验证，并通过允许基因分型和 对参与者样本的单一等分进行测序。

The All of Us Research Program ( AoURP) requires a robust, accurate, and thoroughly CLIA validated sample receipt process, with the capacity to process ~17,000 samples per month at high-quality. To date, the Samples Lab has received, accessioned, and stored over 2 million samples (Figure 2) and has been tested at scale with large national biobanks. To ensure high-quality at high-scale, our processes leverage highly optimized automation with full LIMS tracking to ensure chain of custody and apply various quality control (QC) assays on all incoming samples. We use the same process to receive samples for both genotyping and sequencing. This streamlined approach—that is, performing genotyping and WGS in a single CLIA lab environment—reduces the cost of cross-laboratory sample-identity checking, enables seamless cross-validation of sequencing data with genotype data, and conserves material by allowing genotyping and sequencing to be performed on a single aliquot of a participant’s sample.