CANDIDATE GENE ASSOCIATION RESOURCE (CARE)

候选基因关联资源（CARE）

• 批准号: 7980634
• 负责人: Stacey Gabriel
• 金额: $ 62.34万
• 依托单位: BROAD INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7980634
• 关键词: CANDIDATE; GENE; ASSOCIATION; RESOURCE; CARE

The overall objective of the CARe study is to expand the utilization of NHLBI¿s well-phenotyped observational cohorts and intervention studies for genetic association studies, through the application of large-scale genotyping and widespread data dissemination for genotype-phenotype correlation. The goal is development of a data resource that combines extensive, high-quality genotyping with meticulously standardized phenotyping and rigorous informatic approaches to identify genetic variants related to heart, lung, blood and sleep (HLBS) disorders and their risk factors, and to predict the clinical progression and outcome of these conditions. The NHLBI Large-Scale Genotyping center will perform the following tasks: sample receipt and handling; high-throughput genotyping; integration and documentation of phenotypic data; bioinformatics, data management, data distribution, and administration.

CARe研究的总体目标是通过应用大规模基因分型和基因型-表型相关性的广泛数据传播，扩大NHLBI的良好表型观察队列和干预研究在遗传关联研究中的应用。其目标是开发一种数据资源，将广泛，高质量的基因分型与精心标准化的表型和严格的信息学方法相结合，以识别与心脏，肺，血液和睡眠（HLBS）疾病及其风险因素相关的遗传变异，并预测这些疾病的临床进展和结果。NHLBI大规模基因分型中心将执行以下任务：样本接收和处理;高通量基因分型;表型数据的整合和记录;生物信息学、数据管理、数据分发和管理。