PDX Core

项目摘要-PDX核心 PDX Core为项目研究人员提供了主要资源，包括黑色素瘤PDX、黑色素瘤 细胞系和3D模型，以探索新的治疗方法。黑色素瘤PDX包括450种不同的肿瘤 代表了该病的所有临床和遗传群体。PDX核心的主要焦点是建立 新的PDX并在DNA、RNA和蛋白质水平上协调它们的表征。然后，它维护 掌握细胞库，监测老鼠病原体，并与项目内的其他研究人员合作， 在整个PDTC内部和外部科学家。核心也是用于在内部交换PDX的中央促进器 PDXNet用于协作方面的协调努力。核心协调数据存储和分发，以 该计划内的其他调查人员。 PDX核心可用于对该计划的调查人员进行所有生物分析和模型方面的培训。总的来说， 这一核心将为PDTC内的所有实验室提供高效和高质量的服务。 1

Project Summary – PDX Core The PDX Core provides major resources to the program investigators, including melanoma PDX, melanoma cell lines and 3D models to explore new therapies. The melanoma PDX encompasses >450 different tumors representing all clinical and genetic groups of the disease. The primary focus of the PDX core is to establish new PDX and coordinate their characterization at the DNA, RNA, and protein levels. It then maintains the master cell bank, monitors for mouse pathogens, and collaborates with other investigators within the program, within the overall PDTC and outside scientists. The Core is also to central facilitator for exchanging PDX within the PDXNet for a coordinated effort on collaborations. The Core coordinates data storage and distribution to other investigators within the Program. The PDX Core is available to train investigators of the Program in all biological assays and models. Overall, this Core will provide efficient and high-quality service to all laboratories within this PDTC. 1