Developmental Research Program

项目摘要--发展研究计划 在前一个周期中，Wistar/UPenn孢子发育研究计划(DRP)由Robert博士领导 冯德海德后来成为艾布拉姆森癌症中心的癌症中心主任。《DRP》 从黑色素瘤和皮肤癌研究领域招募了一系列不同的研究人员。结果 有许多杰出的高影响力论文、校外助学金和两个毕业于 在此应用程序中将DRP转换为完整的项目。在这一成功的基础上，Meenhard Herlyn博士和Ravi Amaravadi博士， 这笔孢子赠款的联席董事将在新周期担任DRP联席董事。《公约》的总体目标 在新的资助期间，DRP将继续推进高质量的研究，培养新的想法，推动研究 从试点到项目状态的研究。DRP的第二个目标是为科学工作者创造机会 培养有兴趣过渡到皮肤癌研究的初级教员或高级研究人员。 我们的方法概括为两个具体目标，并通过对特殊水平的坚定承诺而得以实现 来自维斯塔尔研究所和宾夕法尼亚大学的机构支持。DRP将特别欢迎以下项目 非黑色素瘤皮肤癌和未被资助的FULL项目涵盖的主题。目标1是吸引、选择和 资助最杰出的提案，具有显著的潜力，有利于皮肤癌孢子和 转译皮肤癌研究。总结了代表所有癌症的具体研究项目。 皮肤。目标2是支持选定的试点项目，并将其纳入已建立的孢子方案 审查和监测进展情况的流程。妇女和代表不足的少数群体将受到强烈鼓励 参与其中。DRP有一个透明的同行评议的遴选过程，其中纳入了以下方面的定义标准 资金决定。我们要求DRP获奖者积极参与孢子功能，使用孢子核心资源， 并提供正式的书面进度报告。在DRP的框架内，我们建立了高标准 和调查人员的期望，并建立了一个正式程序来审查和监测 资助试点项目。该计划通过出版物、外部资金、激励新目标来衡量成功 在现有的孢子项目中，并为未来提升到完整的项目。

Project Summary – Developmental Research Program In the previous cycle, the Wistar/UPenn SPORE Development Research Program (DRP) was led by Dr. Robert Vonderheide, who has since become the Cancer Center Director of the Abramson Cancer Center. The DRP recruited a diverse array of investigators from many fields into melanoma and skin cancer research. The result has been an outstanding number of high impact papers, extramural grants, and two projects graduating from the DRP into full projects in this application. Building on this success, Dr. Meenhard Herlyn and Dr. Ravi Amaravadi, the co-Directors of this SPORE grant will serve as DRP co-Directors in the new cycle. The overall goals of the DRP in the new grant period remain to advance high quality research, foster new ideas, and move research studies from pilot to project status. A second goal of the DRP is to create opportunities for the scientific development of junior faculty or senior investigators who are interested in transitioning into skin cancer research. Our approach is summarized in 2 specific aims and is enabled by a strong commitment for an exceptional level of institutional support from The Wistar Institute and UPenn. The DRP will, in particular, welcome projects on non-melanoma skin cancers and topics not covered by the funded full Projects. Aim 1 is to attract, select and fund the most outstanding proposals with significant potential to benefit the Skin Cancer SPORE and translational skin cancer research. Specific research projects are summarized that represent all cancers of the skin. Aim 2 is to support and integrate the selected pilot projects into the SPORE program with established processes to review and monitor progress. Women and underrepresented minorities will be strongly encouraged to participate. The DRP has a transparent peer-reviewed selection process that incorporates defined criteria for funding decisions. We require that DRP awardees be active in SPORE functions, use the SPORE Core resource, and provide formal written progress reports. Within the context of the DRP, we have established high standards and expectations of the investigators and have established a formal process to review and monitor progress of funded pilot projects. The Program measures success by publications, extramural funding, stimulating new aims in existing SPORE Projects, and elevation to full projects for the future.