Developmental Research Program

项目摘要-发展研究计划 在上一个周期中，Wistar/UPenn SPORE开发研究计划（DRP）由Robert博士领导 Vonderheide，他后来成为艾布拉姆森癌症中心的癌症中心主任。的DRP 他从各个领域招募了一批不同的研究人员，从事黑色素瘤和皮肤癌的研究。结果 一直是一个杰出的高影响力的论文，校外赠款，和两个项目毕业于 DRP在此应用程序中的完整项目。在这一成功的基础上，Meenhard Herlyn博士和Ravi Amaravadi博士， 此SPORE赠款的联合董事将在新周期中担任DRP联合董事。的总体目标 DRP在新的资助期内仍然致力于推进高质量的研究，培养新的想法，并推动研究 从试点到项目阶段的研究。DRP的第二个目标是为科学创造机会， 发展有兴趣过渡到皮肤癌研究的初级教师或高级研究人员。 我们的方法总结为2个具体目标，并通过对特殊水平的坚定承诺来实现 来自Wistar研究所和宾夕法尼亚大学的机构支持。DRP将特别欢迎以下项目： 非黑色素瘤皮肤癌和未被资助的完整项目覆盖的主题。目标1是吸引、选择和 资助最优秀的提案，这些提案具有使皮肤癌孢子受益的巨大潜力， 转化性皮肤癌研究。具体的研究项目进行了总结，代表所有癌症的 皮肤目标2是支持选定的试点项目并将其纳入SPORE计划， 审查和监测进展的程序。将大力鼓励妇女和代表性不足的少数民族 参与其中DRP有一个透明的同行评审的选择过程，其中包括确定的标准， 融资决策。我们要求DRP获奖者积极参与SPORE功能，使用SPORE核心资源， 并提供正式的书面进度报告。在DRP的范围内，我们制定了高标准 调查人员的期望，并建立了一个正式的程序，以审查和监测 资助的试点项目。该计划通过出版物，校外资金，刺激新目标来衡量成功 在现有的SPORE项目中，并提升到未来的完整项目。

Project Summary – Developmental Research Program In the previous cycle, the Wistar/UPenn SPORE Development Research Program (DRP) was led by Dr. Robert Vonderheide, who has since become the Cancer Center Director of the Abramson Cancer Center. The DRP recruited a diverse array of investigators from many fields into melanoma and skin cancer research. The result has been an outstanding number of high impact papers, extramural grants, and two projects graduating from the DRP into full projects in this application. Building on this success, Dr. Meenhard Herlyn and Dr. Ravi Amaravadi, the co-Directors of this SPORE grant will serve as DRP co-Directors in the new cycle. The overall goals of the DRP in the new grant period remain to advance high quality research, foster new ideas, and move research studies from pilot to project status. A second goal of the DRP is to create opportunities for the scientific development of junior faculty or senior investigators who are interested in transitioning into skin cancer research. Our approach is summarized in 2 specific aims and is enabled by a strong commitment for an exceptional level of institutional support from The Wistar Institute and UPenn. The DRP will, in particular, welcome projects on non-melanoma skin cancers and topics not covered by the funded full Projects. Aim 1 is to attract, select and fund the most outstanding proposals with significant potential to benefit the Skin Cancer SPORE and translational skin cancer research. Specific research projects are summarized that represent all cancers of the skin. Aim 2 is to support and integrate the selected pilot projects into the SPORE program with established processes to review and monitor progress. Women and underrepresented minorities will be strongly encouraged to participate. The DRP has a transparent peer-reviewed selection process that incorporates defined criteria for funding decisions. We require that DRP awardees be active in SPORE functions, use the SPORE Core resource, and provide formal written progress reports. Within the context of the DRP, we have established high standards and expectations of the investigators and have established a formal process to review and monitor progress of funded pilot projects. The Program measures success by publications, extramural funding, stimulating new aims in existing SPORE Projects, and elevation to full projects for the future.