Neurocomputational mechanisms of learning and decision-making and their disruption in addiction

在成瘾和其他神经精神疾病中，激励学习和决策的神经计算机制发生了改变。这些基本过程及其对行为的重要性还没有得到很好的理解。我们正在研究这些问题直接在人类，通过调查学习和决策及其潜在的大脑过程在健康的人使用行为测试和非侵入性神经记录和刺激技术，如高分辨率功能磁共振成像（fMRI）和经颅磁刺激（TMS）。此外，我们探讨这些行为和神经过程是否以及如何在成瘾中改变。更好地了解这些变化可能有助于确定新的干预目标。

Neurocomputational mechanisms underlying incentive learning and decision-making are altered in addiction and other neuropsychiatric conditions. These basic processes, as well as their significance to behavior are not well understood. We are studying these questions directly in humans, by investigating learning and decision-making and their underlying brain processes in healthy humans using behavioral testing and non-invasive neural recording and stimulation techniques, such as high-resolution functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS). In addition, we explore whether and how these behavioral and neural processes are altered in addiction. A better understanding these changes may help to identify new targets for intervention.