Pilot and Feasibility Core

项目总结/摘要 哈佛营养肥胖研究中心（NORC-H）的试点和可行性（P&F）计划提供了 向营养和肥胖研究人员提供高达30，000美元的赠款，这些研究人员需要试点或可行性数据来进行早期测试 假设和/或证明较大赠款申请的可行性。该计划的目标是促进 新颖，前沿的研究，以支持和留住早期职业调查人员，从事广泛的 营养/肥胖研究人员与NORC-H，以促进受援国的成功，并促进 使受援者融入更大的NORC-H社区。每年至少颁发四个新奖项，并且 在竞争的基础上，对进展特别好的项目进行续期， 潜力在可能的情况下，P&F预算得到慈善事业和其他预算来源的补充， 因此，2017-2021年期间，平均每年颁发175，900美元。该计划优先支持 早期职业调查人员，他们在2012-2021年间占受助人的84%，并支持 来自营养或肥胖领域新的知名研究者或来自 研究人员在追求新的研究方向。NORC-H在P&F的投资很高 接受者的成功，并提供多种资源，包括一个专门的辅导计划， 使用核心服务，Lee博士（NORC-H生物统计学家）的生物统计支持，以及 网络，并在年度P&F研讨会上介绍他们的工作。NORC-H行政核心与 博士斯坦利，P&F主任，管理该计划，确保申请人有适当的动物或 人类受试者批准并随时间跟踪奖励和接受者的结果，以判断程序 成功在过去的两个周期（2012-2021年），P&F受援国在利用 P&F资助出版物和进一步的赠款支持。从2012年至2021年，62个奖项，总额150万美元 这些资金已经被用于随后的NIH资金3750万美元，包括5 K级 职业发展赠款和13个R 01。这62个奖项也导致了140个随后的相关 出版物，其中16个是高影响力期刊（影响因子>10）。许多接受者收到了 学术晋升，并已成为成功的独立调查员，和90%的受助人从 2012-2021年仍在营养和肥胖领域工作。上一个赠款周期的方案成功案例 包括（1）致力于增加在医学界代表性不足的科学家的申请， 提高这些奖项的成功率，（2）增加每个周期的申请，以确保高度竞争力 过程资助最有前途的科学，（3）制定一个专门的指导计划， 受惠人士在即将到来的周期中，该计划将为申请人提供额外的资源和教育， 发展成功的导师计划，并继续促进早期职业科学家的职业生涯。

PROJECT SUMMARY/ABSTRACT The Pilot & Feasibility (P&F) Program of the Nutrition Obesity Research Center at Harvard (NORC-H) provides grants of up to $30,000 to investigators in nutrition and obesity who require pilot or feasibility data to test early hypotheses and/or prove feasibility for larger grant applications. The goals of the program are to promote novel, cutting-edge research, to support and retain early career investigators, to engage a wide spectrum of nutrition/obesity researchers with the NORC-H, to promote the success of recipients, and to facilitate the integration of recipients into the larger NORC-H community. At least four new awards are given each year, and renewals are awarded on a competitive basis for projects that have shown particularly good progress and potential. The P&F budget is supplemented with philanthropy and other budgetary sources whenever possible, resulting in an average of $175,900 awarded per year between 2017-2021. The program prioritizes support of early career investigators, who represented 84% of recipients between 2012-2021, and also supports exemplary proposals from established investigators new to the fields of nutrition or obesity or from established investigators within the field pursuing new research directions. The NORC-H is highly invested in P&F recipients’ success and provides multiple resources including a dedicated mentoring program, vouchers for use of Core services, biostatistical support from Dr. Lee (NORC-H biostatistician), and the opportunity to network and present their work at an Annual P&F Symposium. The NORC-H Administrative Core works with Dr. Stanley, the P&F Director, to administer the program, ensuring that applicants have appropriate animal or human subjects approvals and tracking outcomes for awards and recipients over time to judge program success. Over the past 2 cycles (2012-2021), P&F recipients have been highly successful in leveraging the P&F funding into publications and further grant support. From 2012-2021, 62 awards totaling 1.5 million dollars were given; these have been leveraged into 37.5 million dollars of subsequent NIH funding, including 5 K-level career development grants and 13 R01s. The 62 awards have also resulted in 140 subsequent related publications, 16 of which are in high impact journals (impact factor >10). Numerous recipients have received academic promotions and have become successful independent investigators, and 90% of recipients from 2012-2021 are still working in the fields of nutrition and obesity. Program successes over the past grant cycle include (1) dedicated efforts to increase applications from scientists underrepresented in medicine and to increase the success rate of those awards, (2) increased applications per cycle to ensure a highly competitive process funding the most promising science, and (3) development of a dedicated mentoring program for recipients. In the upcoming cycle, the program will provide additional resources and education for applicants, grow the successful mentorship program, and continue to further the careers of early career scientists.