Pilot and Feasibility Program

项目摘要 哈佛NORC-H拥有一个蓬勃发展的P&F计划20年。在过去的10年里，该中心 资助58赠款。这些申请人来自非常有前途的初级研究人员，其中很大一部分是 他们是K资助的，以及数量有限的既定调查员或新的高级调查员 提出了新的研究方向。研究项目通常是临床和转化 符合中心的主题。这些获奖者大大利用了所授予的P&F 资金总额约为1，200，000美元，在随后的NIH基金中产生了超过49，000，000美元，其中包括 大量的R 01赠款。这些P&F赠款成功地帮助我们实现了目标 促进，保留和促进成功的年轻教师营养和肥胖研究。实际上很多 的获奖者现在是中心的调查员和指导自己的初级教师。的首要目标 该中心将促进和促进哈佛营养和肥胖研究，特别关注 转化研究，通过支持新的研究人员，新的项目，创新项目的探索 代表了肥胖和营养研究的一个新方向，由既定的研究人员，并刺激 新的研究人员从其他研究领域从事肥胖和营养研究，并促进和 把这些调查员留在现场。我们的目标是促进营养学的前沿研究， 肥胖，同时促进新一代的研究人员感兴趣，并保留在该领域，以促进 通过对提交的研究报告进行全面的同行审查， 通过举办专题讨论会，积极监测成果和出版物，并充实内容 突出成功的受赠者的工作，并让这些研究人员参与成功的合作， 为了促进我们的受助人赠款的成功，通过：1）使用共享的核心资源， 通过激励措施和对P&F获奖者的收费补贴的权衡制度， 2)为具体的实验策略提供模型开发方面的咨询，以及3）具体的 为P&F申请人提供统计支持，并为获奖者提供持续支持，以促进最佳研究设计。

Project Summary The Harvard NORC-H has had a thriving P&F Program for 20 years. Over the last 10 years, the Center has funded 58 grants. These applicants were from highly promising junior investigators, a large percentage of whom were K funded, as well as a limited number of established investigators or new senior investigators proposing a new direction of research. The research projects were often clinical and translational commensurate with the themes of the Center. These awardees have significantly leveraged the awarded P&F funding totaling approximately $1,200,000, generating over $49,000,000 in subsequent NIH funds, including a significant number of R01 grants. These P&F grants have been successful in helping us to achieve our goals of promoting, retaining and promoting successful young faculty to nutrition and obesity research. In fact many of the awardees are now Center investigators and mentoring their own junior faculty. The overarching goal of the Center is to facilitate and catalyze research in nutrition and obesity at Harvard, with a particular focus on translational research, by supporting the exploration of innovative projects by new investigators, novel projects representing a new direction in obesity and nutrition research by established investigators, and to stimulate new investigators from other areas of research to engage in obesity and nutrition research, and to promote and retain these investigators in the field. Our goals are to promote novel cutting edge research in nutrition and obesity, while promoting a new generation of researchers interested and retained in the field, to promote the engagement of a wide spectrum of the research community, through comprehensive peer review of submitted proposals, active monitoring of results and publications, and enrichment, through organized symposia highlighting the work of the successful grantees and engaging these researchers in successful collaborations, to facilitate the success of our grantees grants through: 1) the use of shared core resources, made uniquely accessible to grantees through an incentives and a weighed system of charge back subsidies to P&F winners 2) provision of consultations in model development for specific experimental strategies, and 3) specific statistical support to P&F applicants and ongoing support to awardees to facilitate optimal study design.