Pilot and Feasibility Program

项目摘要 哈佛NORC-H的P&F项目已经蓬勃发展了20年。在过去的10年里，该中心已经 资助了58笔赠款。这些申请者来自非常有前途的初级调查人员，其中很大一部分 他们得到K资助，以及数量有限的现有调查员或新的高级调查员 提出了新的研究方向。研究项目通常是临床的和翻译的。 与中心的主题相称。这些获奖者极大地利用了获奖的P&F 总计约120万美元的资金，产生了超过4900万美元的NIH后续资金，包括 大量的R01奖助金。这些P&F赠款已经成功地帮助我们实现了我们的目标 促进、留住和提拔成功的年轻教师从事营养和肥胖研究。事实上，很多人 其中的获奖者现在是中心的研究人员，并指导他们自己的初级教员。的首要目标是 该中心将促进和促进哈佛大学在营养和肥胖方面的研究，特别关注 翻译研究，通过支持新研究人员探索创新项目，创新项目 代表了肥胖和营养研究的新方向，由成熟的研究人员，并刺激 来自其他研究领域的新研究人员从事肥胖和营养研究，并促进和 让这些调查人员留在现场。我们的目标是促进营养和营养领域的新型尖端研究 肥胖，同时促进新一代研究人员对该领域感兴趣并保留下来，以促进 通过对提交的材料进行全面同行审查，广泛参与研究界 提案，积极监测成果和出版物，并通过有组织的研讨会丰富内容 强调成功的受赠者的工作并使这些研究人员参与成功的合作， 为了促进我们受赠者赠款的成功，通过：1)使用共享的核心资源，以独特的方式 获奖者可通过奖励和向P&F获奖者收取补贴的权衡制度获得 2)为具体的实验策略提供模型开发方面的咨询，以及3)具体的 对P&F申请者的统计支持和对获奖者的持续支持，以促进最佳研究设计。

Project Summary The Harvard NORC-H has had a thriving P&F Program for 20 years. Over the last 10 years, the Center has funded 58 grants. These applicants were from highly promising junior investigators, a large percentage of whom were K funded, as well as a limited number of established investigators or new senior investigators proposing a new direction of research. The research projects were often clinical and translational commensurate with the themes of the Center. These awardees have significantly leveraged the awarded P&F funding totaling approximately $1,200,000, generating over $49,000,000 in subsequent NIH funds, including a significant number of R01 grants. These P&F grants have been successful in helping us to achieve our goals of promoting, retaining and promoting successful young faculty to nutrition and obesity research. In fact many of the awardees are now Center investigators and mentoring their own junior faculty. The overarching goal of the Center is to facilitate and catalyze research in nutrition and obesity at Harvard, with a particular focus on translational research, by supporting the exploration of innovative projects by new investigators, novel projects representing a new direction in obesity and nutrition research by established investigators, and to stimulate new investigators from other areas of research to engage in obesity and nutrition research, and to promote and retain these investigators in the field. Our goals are to promote novel cutting edge research in nutrition and obesity, while promoting a new generation of researchers interested and retained in the field, to promote the engagement of a wide spectrum of the research community, through comprehensive peer review of submitted proposals, active monitoring of results and publications, and enrichment, through organized symposia highlighting the work of the successful grantees and engaging these researchers in successful collaborations, to facilitate the success of our grantees grants through: 1) the use of shared core resources, made uniquely accessible to grantees through an incentives and a weighed system of charge back subsidies to P&F winners 2) provision of consultations in model development for specific experimental strategies, and 3) specific statistical support to P&F applicants and ongoing support to awardees to facilitate optimal study design.