BEHAVIORAL PHENOTYPING CORE

项目总结/摘要-行为表型核心 行为表型核心（BPC）支持开发，实施和传播 广泛的科学调查集中在理解影响大脑发育的机制， 行为和认知的个体智力和发育障碍（IDD）。独特的核心 属性包括：（1）通过一个 超过27，000名具有深度神经认知/行为表型的个体的登记和研究数据库; (2)在评估和干预功能非常低下的人，包括那些 有感觉、运动和/或沟通障碍的人，以及有最严重和最具挑战性的人。 行为;（3）通过可穿戴和基于视频的评估实施远程评估的能力 技术;（4）超过500个经验证的定量神经心理学和行为评估的目录 仪器，准备在临床试验中通过训练有素的检查员实施;（5）最先进的运动 分析单元配备运动成像、机器人技术、力分析、感觉和本体感受 测量能力;和（6）临床和研究神经生理学资源，包括全方位的 通过脑电图和多导睡眠描记仪进行测量。这些独特的核心功能允许 研究人员调查IDD的全方位生物标志物（神经影像学，生理学，“组学”），并将其与IDD的生物标志物联系起来。 这些直接影响到人类的深层行为表型。 具体目标主要通过核心教师的专业知识与资源的整合来实现， 设施、设备和来自核心内四个互补单位的直接服务，包括行为 分析，运动分析，发展神经心理学和临床神经生理学。与这些富有和 多样化的资源，开发和验证广泛的临床试验准备结果指标 沿着的还有传播或资源以及科学 发现。

PROJECT SUMMARY/ABSTRACT – BEHAVIORAL PHENOTYPING CORE The Behavioral Phenotyping Core (BPC) supports development, implementation, and dissemination of a broad spectrum of scientific inquiries focused on understanding mechanisms affecting brain development, behavior, and cognition among individuals with intellectual and developmental disabilities (IDD). Unique Core attributes include: (1) access to data about a wide range of genetic and neurodevelopmental disorders, via a registry and research database of over 27,000 individuals with deep neurocognitive/behavioral phenotyping; (2) significant expertise in assessment and intervention with very low functioning individuals, including those with sensory, motor, and/or communication impairments, and individuals with the most severe and challenging behaviors; (3) ability to implement remote assessments through wearable and video-based assessment technology; (4) a catalog of over 500 validated quantitative neuropsychological and behavioral assessment instruments, ready to implement in clinical trials via highly- trained examiners; (5) a state-of-the-art motion analysis unit equipped with movement imaging, robotics, force analysis, sensation and proprioception measurement capabilities; and (6) clinical and research neurophysiology resources, including a full range measurements available through EEG and polysomnography. These unique Core features allow for researchers to investigate the full range of biomarkers (neuroimaging, physiologic, “-omic”) in IDD, and to link these directly to deep behavioral phenotyping in humans. Specific aims are accomplished primarily through the integration of Core faculty expertise with resources, facilities, equipment, and direct services from four complementary units within the Core, including behavior analysis, motion analysis, developmental neuropsychology and clinical neurophysiology. With these rich and diverse resources, development and validation of a wide range of outcome measures for clinical trial readiness in IDD, is a fundamental component of the Core, along with dissemination or resources and scientific discoveries.