Pharmacometrics and Analytical Chemistry Core

药物计量学和分析化学核心(PACC)将推动这一多学科UC的目标 圣地亚哥MPRINT CET提案通过与临床、基础和医学中心开展高度协调的研究活动 研究和数据科学项目以及牛奶分析核心，得到行政核心的指导。 将生成精确、高质量的翻译和临床药代动力学(PK)数据，以帮助解决 在每个项目中都提出了假设。支持PACC的基础设施在于已建立的和 高效的加州大学圣地亚哥分校儿科药理实验室(PPL)在斯卡格斯学院 药学与药学和儿科。临床基础课程的具体目标 科学和数据科学项目需要量化抗生素、其代谢物和治疗性 各种临床和动物模型矩阵中的效应标记。PACC完全有资格进行这些工作 定量分析，并有与以下相关的小体积和不同种类基质的经验 项目将产生的PK样本，包括母乳。PACC拥有先验和 在血浆、血清、全血、尿液、脑脊液、胎粪、 毛干，以及所有哺乳动物的组织类型。此外，PACC将继续扩大其 除母体化合物外，还包括对药物代谢物进行量化的能力。量化 母乳、血浆和其他基质中药物和代谢物的分析将通过LC-MS/MS和/或 高效液相色谱-紫外检测法。PACC还将为项目负责人提供专门和专门的PK分析，包括 创新的PK建模和仿真以及基于生理的PK(PBPK)建模。最后，PACC将 提供最佳的研究和培训环境，支持临床、基础科学和 翻译科学项目。

The Pharmacometrics and Analytical Chemistry Core (PACC) will further the goals of this multidisciplinary UC San Diego MPRINT CET proposal by conducting highly coordinated research activities with the Clinical, Basic Research and Data Science Projects and the Milk Analytics Core, with guidance from the Administrative Core. Precise, high quality translation and clinical pharmacokinetic (PK) data will be generated to help address hypotheses raised in each of the Projects. The infrastructure enabling the PACC lies in the established and highly productive UC San Diego Pediatric Pharmacology Laboratory (PPL) within the Skaggs School of Pharmacy and Pharmaceutical Sciences and Department of Pediatrics. Specific Aims of the Clinical, Basic Science and Data Science Projects require quantification of antibiotics, their metabolites, and therapeutic effects markers in a variety of clinical and animal model matrices. The PACC is well qualified to conduct these quantitative assays and has experience with the small volumes and heterogeneous matrices associated with PK samples that will be generated by the Projects, including breastmilk. The PACC possesses prior and contemporary expertise in the processing of plasma, serum, whole blood, urine, cerebrospinal fluid, meconium, hair shaft, as well as all mammalian tissue types. Additionally, the PACC will continue to expand upon its capabilities to include quantification of drug metabolites in addition to their parent compounds. Quantification of drugs and metabolites in breast milk, plasma, and other matrices will be accomplished by LC-MS/MS and/or HPLC-UV. The PACC will also offer dedicated and specialized PK analysis to Project Leaders, including innovative PK modeling and simulation and physiologically-based PK (PBPK) modeling. Finally, the PACC will provide an optimal research and training environment in which to support the Clinical, Basic Science, and Translational Science Projects.