Regulated cell death and responses to starvation in cancer

摘要 细胞通过上调促进生存的适应机制或通过 当压力太大时经历细胞死亡。癌细胞利用压力 反应，以便在恶劣的癌症微环境中生存，并了解哪些 利用适应性机制来避免细胞死亡是获得新知识的关键，可能 被用于癌症治疗。同样清楚的是，不是一个，而是实际上有很多个 不同形式的细胞死亡可以对压力作出反应，我们的研究做出了贡献 尤其是在这一地区。我们已经证明，某些机制对生物多样性具有独特的影响。 细胞群体的动态，其中一些促进治疗，而另一些可能阻碍治疗 回应。我们提出的研究计划将集中在两个主要的发现领域：(1)如何 细胞死亡是否受到应激反应的调节，以及特定的机制是如何促进 控制种群动态？(2)细胞如何通过适应性适应来应对营养饥饿 涉及溶酶体的机制？我们将利用我们拥有的最新发现和方法 旨在通过一套完整的细胞生物学来研究这些首要问题 以影像研究为重点的方法。

Abstract Cells respond to stress by upregulating adaptive mechanisms that promote survival or by undergoing cell death when the stress is too severe. Cancer cells take advantage of stress responses in order to survive within harsh cancer microenvironments, and understanding which adaptive mechanisms are utilized to avoid cell death is critical to gaining new knowledge that may be exploited for cancer therapy. It has also become clear that there is not one, but in fact many different forms of cell death that can occur in response to stress, and our studies have contributed significantly in this area. We have shown that some mechanisms have unique effects on the dynamics of cell populations, and that some promote, while others may hinder, therapeutic responses. Our proposed research program will focus on two major areas of discovery: (1) How is cell death regulated in response to stress, and how do particular mechanisms contribute to controlling population dynamics? (2) How do cells respond to nutrient starvation through adaptive mechanisms that involve lysosomes? We will exploit recent findings and methods we have developed to study these overarching questions through an integrated set of cell biological approaches with a focus on imaging-based studies.