Understanding the biological regulation of MLKL and its role in necroptotic cell death

细胞死亡是一个正常的过程，它允许我们的重要组织生长和防御。坏死性上睑下垂是一种细胞死亡，其特征是细胞肿胀和破裂。当细胞以这种不受控制的方式“爆炸”时，它们会引发炎症反应。这可能是从结肠炎到心血管疾病等疾病背后的一个因素。了解坏死性细胞死亡可能为那些遭受这些毁灭性疾病折磨的人铺平道路。

Cell death is a normal process that permits the growth and defence of our vital tissues. One kind of cell death, necroptosis, is characterized by the swelling and bursting of cells. When cells ‘explode’ in this uncontrolled way they provoke an inflammatory response. This may be a factor behind illnesses ranging from colitis to cardiovascular disease. Understanding necroptotic cell death may pave the way for new therapies for those that suffer from these devastating conditions.