Understanding the biological regulation of MLKL and its role in necroptotic cell death

了解 MLKL 的生物调节及其在坏死性细胞死亡中的作用

• 批准号: nhmrc : 1105023
• 负责人: Dr Joanne Hildebrand
• 金额: $ 45.03万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-biological-regulation-cell-death/662797
• 关键词: Understanding; biological; regulation; MLKL; its

Cell death is a normal process that permits the growth and defence of our vital tissues. One kind of cell death, necroptosis, is characterized by the swelling and bursting of cells. When cells ‘explode’ in this uncontrolled way they provoke an inflammatory response. This may be a factor behind illnesses ranging from colitis to cardiovascular disease. Understanding necroptotic cell death may pave the way for new therapies for those that suffer from these devastating conditions.

细胞死亡是一个正常的过程，允许我们重要组织的生长和防御。坏死性凋亡是一种细胞死亡，其特征是细胞肿胀和破裂。当细胞以这种不受控制的方式“爆炸”时，它们会引起炎症反应。这可能是从结肠炎到心血管疾病等疾病背后的一个因素。了解坏死性细胞死亡可能为那些患有这些毁灭性疾病的人的新疗法铺平道路。