Transferring Speed of Processing Gains to Everyday Cognitive Tasks after Stroke

摘要 此多样性补充申请与资助补助金R 01 AG 070049（标题：转让 处理速度对日常生活的影响; PI：E。Taub;项目周期：9/5/2021- 8/31/2022）。这 申请要求资金提供神经康复研究的培训，以拟议的多样性 补充候选人与临床研究由母基金支持。 父母补助金的目的是进行一项随机对照试验（RCT），以评估 一种新的治疗方法，约束诱导（CI）认知疗法，改善认知障碍的疗效， 慢性中风患者。CI认知疗法结合了两种反复验证的康复方法： CI运动疗法转移包与认知加工速度训练。的目的 这样做是为了显著增强认知改善从训练环境中的转移 工具性日常生活活动（IADL）。新组合的两半 治疗是建立在研究者自己的基础研究之上的。在这两种情况下，疗效都得到了积极的支持， 结果来自多个单中心RCT和一个大型多中心RCT。然而，处理速度的影响 训练（SOPT）已被发现有有限的推广到认知为基础的日常生活能力在日常生活中的情况。 相比之下，CI疗法的主要优势之一是它产生了一个强大而广泛的转移， 治疗效果，以日常生活的情况下，部分手段，其转让包（TP）。 父母补助金涉及一项单盲RCT，分为两组：SOPT + TP vs. SOPT + TP。 TP.参与者将是120名中风后超过1年的轻度至中度认知障碍的成年人。 认知任务的表现将在日常生活和实验室中在基线之前和之后， 治疗，以及6个月和12个月后。 扩大多样性补充候选人的研究技能，并促进她作为一个 作为一名独立的科学家，这项申请提出了一个为期两年的教学培训计划， 在赠款写作和数据分析，动手训练的设计和神经康复研究的行为， 独立研究活动，手稿和赠款申请开发，以及在 科学会议。

ABSTRACT This Diversity Supplement application is connected to funded grant R01 AG070049 (Title: Transferring Speed of Processing Gains to Everyday Life; PI: E. Taub; Project Period: 9/5/2021- 8/31/2022). This application requests funds to provide training in neurorehabilitation research to the proposed Diversity Supplement candidate in association with the clinical study supported by the parent grant. The purpose of the parent grant is to conduct a randomized controlled trial (RCT) to evaluate the efficacy of a new treatment, Constraint-Induced (CI) Cognitive Therapy, for improving cognitive impairment in patients with chronic stroke. CI Cognitive Therapy combines two repeatedly validated rehabilitation methods: the Transfer Package of CI Movement Therapy and Speed of Cognitive Processing Training. The purpose of doing so is to produce a marked enhancement in the transfer of cognitive improvement from the training setting to instrumental activities of daily living (IADL) in everyday situations. Both halves of the new combination therapy are founded on the investigators’ own basic research. In both cases, efficacy is supported by positive results from multiple single-site RCTs and a large multisite RCT. However, the effect of Speed of Processing Training (SOPT) has been found to have limited generalization to cognitive-based IADL in everyday situations. In contrast, one of the main strengths of CI Therapy is that it produces a robust and extensive transfer of treatment effect to everyday life situations by means, in part, of its Transfer Package (TP). The parent grant involves a single-blind RCT with two arms: SOPT with the TP vs. SOPT without the TP. Participants will be 120 adults more than 1-year post-stroke with mild to moderate cognitive impairment. Performance on cognitive tasks will be measured in daily life and in the lab before and after baseline, after treatment, and 6- and 12-months afterwards. To expand the research skills of the Diversity Supplement candidate and foster her development as a career as an independent scientist, this application proposes a two-year, structured program of didactic training in grant writing and data analysis, hands-on training in the design and conduct of neuro-rehabilitation research, independent research activity, manuscript and grant application development, and presentation of data at scientific conferences.