NICHD Cooperative Multicenter Neonatal Research Network

项目摘要 爱荷华州的大学提交此更新申请继续参与NICHD 新生儿研究网络（RFA-HD-23-002）。我们寻求继续支持全国重建部队的使命 改善新生儿的医疗保健和结果，寻求解决方案，以提高生存率， 早产儿和危重新生儿的神经发育障碍或慢性疾病。我们 有几个优势，将促进NRN的合作工作。 1.我们的新生儿重症监护病房是世界领先的围产期婴儿护理，出生在22和23周的妊娠。 爱荷华州大学的这个种群的存活率是美国最好的， 这些幸存者中的大多数没有神经发育障碍。我们带来专业知识， 研究设计以及相对较大的可参与NRN的围产期人群 问题研究我国极低出生体重婴儿的死亡率常年处于全国最低之列。 2.我们在婴儿临床研究方面有着深厚的传统和文化。我们的临床研究 NICU的基础设施具有数十年成功参与多中心 研究和重要的新生儿研究成果的贡献。 3.我们的新生儿重症监护室是美国领先的中心，在新生儿的新兴新生儿亚专科 血流动力学我们的血流动力学小组已经开发了研究方法和超声心动图 是该模式的测量标准，并且是临床和临床使用的全球专家。 生理和介入研究。这种专业知识可以在NRN中利用， 研究设计。 4.作为一个以农业为经济基础的农村州唯一的学术医疗中心， 我们所代表的人群在NICHD网络中没有得到很好的代表。我们的合作伙伴 位于南达科他州苏福尔斯的桑福德健康中心的一个站点进一步增强了这种多样性， 美国人口和农村人口的总和。如果网络研究的结果是 推广到全国各地的患者，应该代表全国的这一大片地区。 爱荷华州网络中心的大学代表这一地区和人口。 5.在过去的7年里，我们为NRN的工作做出了重大贡献。我们一直 尽管我们的人口相对较少，但在几项研究中， 在试验和随访观察研究中，对婴儿的随访率都很高。

Project Summary The University of Iowa submits this renewal application for continued participation in the NICHD Neonatal Research Network (RFA-HD-23-002). We seek to continue to support the mission of the NRN to improve healthcare and outcomes for newborns, seeking solutions to increase survival without neurodevelopmental impairment or chronic illness for premature and critically ill newborn infants. We have several strengths that will advance the collaborative work of the NRN. 1. Our NICU is a world leader in the care of periviable infants, born at 22 and 23 weeks’ gestation. The survival rate of this population at the University of Iowa is the best in the United States, and the majority of these survivors are free of neurodevelopmental impairment. We bring expertise to inform research design as well as a relatively large periviable population available to participate in NRN studies. Our mortality for extremely low birth weight infants is perennially among the lowest in the NRN. 2. We have a strong tradition and culture of clinical research in infants. Our clinical research infrastructure in the NICU has a decades-long track record of successful participation in multicenter studies and contributions to important neonatal study findings. 3. Our NICU is the leading US center in the emerging neonatal subspecialty of neonatal hemodynamics. Our Hemodynamics group has developed the study methods and echocardiographic measurement standards for this modality and are global experts in its use both clinically and in physiologic and interventional research. That expertise can be harnessed in the NRN to pursue novel study designs. 4. As the only academic medical center in a largely rural state with an economy based in agriculture, we represent a population that is not otherwise well represented in the NICHD Network. Our partner site at Sanford Health in Sioux Falls, SD further enhances this diversity with the addition of a Native American population to our combined rural population. If the results of Network studies are to be generalized to patients throughout the country, this large area of the country should be represented. The University of Iowa Network center represents this region and population. 5. We have contributed significantly to the NRN’s work through the last 7 years. We have been among the highest enrolling sites in several studies despite our relatively low population, and we have had excellent follow-up rates for infants both in trials and in the Follow-up observational study.