Maternal-Fetal Medicine Units (MFMU) Network

位于伯明翰的亚拉巴马大学（UAB）的母胎医学（MFM）分部提交了这份报告。 申请继续作为NICHD MFM单位（MFMU）网络的临床中心。我们展示我们中心的 在网络中的卓越表现的属性和长期记录。我们仍然致力于 该网络的目标是改善产科护理、妊娠健康和孕妇/哺乳期妇女的结局， 他们的孩子我们的国际知名的妇女生殖健康中心（CWRH），我们的家庭 MFMU中心，拥有超过50名研究人员和丰富的成功经验，领导大型临床试验， 观察性研究，以改变网络内外的孕产妇和婴儿健康。作为MFMU 在超过30年的时间里，UAB一直在为网络提供管理方面发挥领导作用， 指导委员会和小组委员会级别，以最高的效率进行网络试验， 中心，并导致所有中心的演示和出版的数据产生。在32个临床中心中， MFMU历史，UAB研究员首次撰写了>17%的网络出版物（自2016年以来为14.5%）和18%的 在国家会议上发言。我们团队的现有成员已经积累了>250 MFMU人年 积极参与支持MFMU项目的经验;我们的研究人员同样积累了>275 MFMU 人年Alan Tita，MD，PhD（CWRH主任）和Brian凯西，MD将继续担任PI和替代PI， 分别我们的团队包括2名前MFMU PI和7名曾担任或目前担任 网络协议主席或小组委员会成员。我们继续招收和保留最高人数 的参与者在许多网络研究;调整现有的人口，我们招收最高的任何MFMU 绝佳的价钱我们丰富的高风险和多样化的人口（>50%黑人），强大的研究支持文化， 协作，24/7研究人员覆盖率和高比例的筛选合格患者成功入组 网络研究使我们能够维持和继续这种高水平的性能。如果这次续约成功， 我们将加强与Ochsner卫生系统作为卫星站点的合作。我们将部署我们广泛的 研究资源-数据管理系统，招聘资源，包括电子编程 健康记录，跨学科调查小组和经验丰富的人员-构思，设计和 实施新的创新和有影响力的研究。我们将利用网络来培养未来的研究领导者 包括我们下一任私家侦探我们的成功记录延伸到互补的大型非MFMU财团的领导 进行有影响力的临床试验和后续研究，以实现类似的目标，包括慢性 高血压和妊娠联盟和美国心脏协会健康公平研究网络 关于母婴健康结果的差异。自2016年以来，我们的核心MFM调查人员有>260名非MFMU 同行评审的出版物。我们相信我们中心的属性在此详述，持续的成功记录， 我们计划优先考虑MFMU研究，使我们能够在新的7年周期中取得成功。

The Maternal-Fetal Medicine (MFM) Division of the University of Alabama at Birmingham (UAB) submits this application to continue as a clinical center of the NICHD MFM Units (MFMU) Network. We present our center's attributes and longstanding record of exceptional performance in the Network. We remain committed to the Network's goals to improve obstetric care, pregnancy health, and outcomes for pregnant/lactating people and their babies. Our internationally-renowned, Center for Women's Reproductive Health (CWRH), the home of our MFMU center, has a research staff of >50 and extensive successful experience leading large clinical trials and observational studies to transform maternal and infant health both in and outside the Network. As an MFMU center for >30 years, UAB has consistently played a leadership role in providing stewardship for the Network at the Steering Committee and sub-committee levels, conducted Network trials with the highest efficiency of any center, and led all centers in the presentation and publication of data generated. Among 32 clinical centers in MFMU history, a UAB investigator first-authored >17% of Network publications (14.5% since 2016) and 18% of presentations at national meetings. Current members of our team have accumulated >250 MFMU person-years' experience of active participation supporting MFMU projects; our research staff similarly cumulate >275 MFMU person-years. Alan Tita, MD, PhD (CWRH Director) and Brian Casey, MD will continue as PI and Alternate PI, respectively. Our team includes 2 previous MFMU PI's and 7 members who have served or currently serve as Network protocol chairpersons or Subcommittee members. We continue to enroll and retain the highest number of participants in many network studies; adjusted for the available population, we enroll the highest of any MFMU site. Our enriched high-risk and diverse population (>50% black), strong culture of research support and collaboration, 24/7 research staff coverage and high proportion of screen-eligible patients successfully enrolled into network studies allow us to sustain and continue this high level of performance. If successful in this renewal, we will strengthen our collaboration with Ochsner Health System as a satellite site. We will deploy our extensive research resources - data management systems, recruitment resources including programming into electronic health records, transdisciplinary investigative team and experienced personnel - to conceive, design and implement new innovative and impactful studies. We will leverage the network to train future research leaders including our next PI. Our record of success extends to leadership of complementary large non-MFMU consortia conducting impactful clinical trials and follow-up studies towards similar goals, including the Chronic Hypertension and Pregnancy consortium and the American Heart Association Health Equity Research Network on Disparities in Maternal-Infant Health Outcomes. Since 2016 our core MFM investigators had >260 non-MFMU peer-reviewed publications. We believe our center's attributes detailed herein, the sustained record of success, and our plans to prioritize MFMU studies position us for success during the new 7-year cycle.