Integrative Approach to Comprehensive Analysis of High Throughput Data on a Cancer Center Level

项目摘要 生物信息学设施，由授予Wistar研究所的癌症中心支持赠款(CCSG)支持， 在多个研究项目上与绝大多数癌症中心成员合作。我作为一名科学家的角色 生物信息学设施主任将参与其中许多研究计划的所有步骤。这个 全研究所参与与癌症相关的研究使我能够开发全面的数据分析 适用于多个程序的管道，以及重复使用结果元素，包括数据库、 对数据集和其他综合资源进行汇总和注解，并根据具体情况进行分析 学习。与具体项目的研究工作相结合，这反过来又有助于现有的 Knowledgebase，综合方法为应用方法提供了强大的科学环境 计算生物学在各种癌症相关研究中的应用演示。

Project Summary Bioinformatics Facility, supported by the Cancer Center Support Grant (CCSG) awarded to the Wistar Institute, collaborates with the vast majority of cancer center members on multiple research projects. My role as a Scientific Director of the Bioinformatics Facility is to be engaged on all steps of many of those research programs. The institute-wide involvement in cancer-related studies allows me to develop comprehensive data analyses pipelines applicable across multiple programs, as well as to re-use result elements, including databases, summarized and annotated datasets and other integrative resources, in analyses customized to particular studies. In combination with project-specific research efforts, which in turn contribute to the existing knowledgebase, the integrative approach provides a robust scientific environment for applying methods of computational biology to various cancer-related studies as demonstrated in the application.