A Community Resource for Single Cell Data in the Brain

项目摘要 脑倡议细胞图谱网络（BICAN）将产生全面的分子分类， 细胞类型多样性的组织原则在人类和非人类灵长类动物延伸全面 BICCN在小鼠中起作用。这种详细的普查的结构和作用的细胞类型的具体数据在大脑中 被认为是促进我们对人类大脑理解的最有前途的途径之一， 健康和疾病。为了促进BICAN的成功运作，该项目将建立一个约定， 联合体的外联和协调股，负责管理业务、基本标准 开发和记录，提供运营透明度，并确定和协调解决方案， 协作和分析的关键障碍。除了组织虚拟会议和面对面会议外， BICAN网络和工作组该单位将提高互操作性和与其他联盟的一致性 和合作伙伴，旨在改善广泛的潜在数据消费者的使用。为补充这些 BICAN联合体和合作伙伴CUBIE单位的基本业务目标，该单位将提供一个 BICAN数据生成和发布的生成和操作透明度的治理结构， 标准制定。基本活动将包括技术管理和促进社区 标准、模式和本体开发，以及集中式联盟数据注册和仪表板， 协调和组织BICAN外联、培训和教育活动，以加强互动 与外部研究项目和财团合作。由此产生的联盟生成的数据和工具将 在支持数据检索的社区门户网站上向公众开放，联盟活动，扩大公众 通过强大的BICAN合作伙伴关系管理、沟通、标准委员会和分析产生影响 工作组，并开发基础设施，以最大限度地提高社区的使用，发布标准， 辅导，并协调教育和推广。

Project Summary The BRAIN Initiative Cell Atlas Network (BICAN) will generate comprehensive molecular taxonomies and organizational principles of cell type diversity in the human and non-human primate extending comprehensive BICCN work in the mouse. This detailed census of the structure and role of cell type specific data in the brain is recognized as one of the most promising avenues for advancing our understanding of the human brain in health and disease. To facilitate successful operations for BICAN, this project will establish an engagement, outreach, and coordination unit for the consortium that will manage operations, essential standards development and documentation, provide operational transparency, and identify and coordinate solutions to key hurdles for collaboration and analysis. In addition to organizing virtual and in-person meetings of the BICAN network and working groups this unit will improve interoperability and alignment with other consortia and partners and aim to improve usage for a wide range of potential data consumers. Complementing these fundamental operational goals of the BICAN consortium and partner CUBIE units, this unit will provide a governance structure for generation and operational transparency of BICAN data production and release and standards development. Essential activities will include technical management and facilitation of community standards, schemas, and ontology development, and centralized consortium data registration and dashboard, and coordinating and organizing BICAN outreach, training, and education activities to enhance interactions with external research programs and consortia. The resulting consortium generated data and tools will be made publicly accessible in a community portal supporting data retrieval, consortium activities, amplify public impact through strong BICAN partnership management, communication, standards committees, and analysis working groups, and develop infrastructure for maximizing community usage, publishing standards and tutorials, and coordinating education and outreach.