CD74 and Wound Healing

项目摘要 粘膜上皮屏障在许多情况下被破坏，例如外科手术，创伤， 炎症性肠病、局部缺血、感染、放疗和化疗。上皮细胞再生是 对粘膜伤口闭合和愈合至关重要。 我们的总体目标是了解导致有效粘膜伤口闭合的机制。这项建议 基于我们最近发现的涉及CD74信号传导的肠粘膜创伤修复机制。 CD74是MIF细胞因子的受体。 该提案旨在解决CD74信号通路中尚未解决的重要问题 和伤口修复，值得探索我们的研究是基于我们的三个关键问题， 已发表的和初步的数据：驱动上皮CD74受体表达的机制是什么（目的 （1）？我们能安全有效地刺激CD74（Aim 2）吗？人类的功能性后果是什么 CD74活性的遗传变异（目的3）？ 从这些研究中获得的知识将大大促进我们对CD74机制的理解 生物学和粘膜伤口修复，并可能导致新的治疗策略，促进粘膜伤口 治愈

Project Summary The mucosal epithelial barrier becomes disrupted in many conditions such as surgical procedures, trauma, inflammatory bowel diseases, ischemia, infections, radiation, and chemotherapy. Epithelial cell regeneration is essential for mucosal wound closure and healing. Our overall goal is to understand the mechanisms that lead to effective mucosal wound closure. This proposal builds on our recent discovery of an intestinal mucosal wound repair mechanism involving CD74 signaling. CD74 is the receptor for the MIF cytokine. The proposal aims to address significant questions that remain unanswered in the CD74 signaling pathway and wound repair, and are worth exploring. Our research is motivated by three key questions based on our published and preliminary data: What is the mechanism that drives epithelial CD74 receptor expression (Aim 1)? Can we safely and effectively stimulate CD74 (Aim 2)? What are the functional consequences of human genetic variation on CD74 activity (Aim 3)? Knowledge gained from these studies will significantly advance our mechanistic understanding of CD74 biology and mucosal wound repair, and may lead to new therapeutic strategies for promoting mucosal wound healing.