CD74 and Wound Healing

CD74 和伤口愈合

• 批准号: 10897552
• 负责人: Shannon Moonah
• 金额: $ 37.18万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-16 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10897552
• 关键词: CD74; Wound; Healing

Project Summary The mucosal epithelial barrier becomes disrupted in many conditions such as surgical procedures, trauma, inflammatory bowel diseases, ischemia, and infections. Epithelial cell regeneration is essential for mucosal wound closure and healing. Our overall goal is to understand the mechanisms that lead to effective mucosal wound closure. This proposal builds on our recent discovery of a novel intestinal mucosal wound repair mechanism involving CD74 signaling. CD74 is the receptor for the MIF cytokine. Our research is motivated by three important and innovative questions: What is the mechanism that drives epithelial CD74 receptor expression (Aim 1)? Can we safely and effectively stimulate CD74 (Aim 2)? What are the functional consequences of genetic variation on CD74 activity (Aim 3)? Knowledge gained from these studies will advance our mechanistic understanding of CD74 biology and mucosal wound repair, and may lead to new therapeutic strategies for promoting mucosal wound healing.

项目摘要 粘膜上皮屏障在许多情况下被破坏，例如外科手术，创伤， 炎症性肠病、局部缺血和感染。上皮细胞再生是粘膜修复的关键。 伤口闭合和愈合。我们的总体目标是了解导致有效粘膜保护的机制。 伤口闭合 这一建议建立在我们最近发现的一种新的肠粘膜创伤修复机制的基础上， CD74信号转导。CD74是MIF细胞因子的受体。我们的研究是由三个重要的动机， 创新问题：驱动上皮CD74受体表达的机制是什么（目标1）？我们能 安全有效地刺激CD74（目标2）？基因变异对人类的功能有什么影响？ CD74活性（目标3）？ 从这些研究中获得的知识将促进我们对CD74生物学的机械理解， 粘膜伤口修复，并可能导致新的治疗策略，促进粘膜伤口愈合。

项目成果

Pro-Survival Pathway Protects from C. difficile Toxin-Mediated Cell Death.

促生存途径可防止艰难梭菌毒素介导的细胞死亡。

• DOI: 10.1093/infdis/jiad481
• 发表时间: 2023
• 期刊: The Journal of infectious diseases
• 作者: Tornel,William;Sharma,Ishrya;Osmani,Hiba;Moonah,Shannon
• 通讯作者: Moonah,Shannon