Bioinformatics

摘要-生物信息学共享资源 生物信息学共享资源由癌症中心管理，提供尖端生物信息学， 基因组学和生物统计学支持；推动计算创新；提供咨询和培训，以 所有中心成员。该中心的使命是促进和协助癌症中心的研究人员通过一系列 提供各种服务，从执行数据分析到培训研究人员使用软件/硬件。 因此，中心提供的服务极大地加强了调查人员的研究工作，并有助于 从生物学数据集中生成并在实验上验证研究假设。核心继续 为中心的科学目标作出重大贡献，并在其培训任务中组织了一次 举办了一些生物信息学和统计学培训班，并举办了个性化培训班和教程。 核心已经为新的基因组技术实施了几个工作流程，开发了一台先进的机器 基于学习的Web服务(Regulattice)，用于分析和可视化各种不同的监管网络 此外，还为蛋白质组学核心实施了自动文件传输和信息系统。一种新的 核心设施主任尹俊博士于2019年初受聘。从那时起，一个全面的 NGS分析软件包、OmicSoft阵列套件和前处理癌症基因组学数据服务器， OmicSoft Oncoland，已经获得许可。一台新的Dell PowerEdge R530服务器和一台新的PSSC High 已安装性能计算(HPC)服务器以提供广泛的计算支持。96 TB 还安装了网络连接驱动器(NAD)，用于大规模基因组数据集管理和 后备。在过去5年中，该中心为37 代表所有三个项目的中心成员为18个赠款申请提供了支持，70多个 癌症相关出版物

ABSTRACT – BIOINFORMATICS SHARED RESOURCE The Bioinformatics Shared Resource, managed by the Cancer Center, provides cutting-edge bioinformatics, genomics, and biostatistics support; drives computational innovation; and provides consultation and training to all Center members. The Core's mission is to facilitate and assist Cancer Center researchers through an array of services ranging from execution of data analysis to training of researchers in the use of software/hardware. As such, the services provided by the Core greatly enhance the investigators' research efforts and help to generate and experimentally validate research hypotheses from biological datasets. The Core continues to contribute significantly to the scientific objectives of the Center, and in its training mission, has organized a number of bioinformatics and statistics training classes and hosted personalized training sessions and tutorials. The Core has implemented several workflows for new genomics technologies, developed an advanced machine learning-based web service (Regulattice) for the analysis and visualization of regulatory networks in various cancers, and implemented an automated file transfer and information system for the Proteomics Core. A new Facility Director for the Core, Dr. Jun Yin, was recruited at the start of 2019. Since that time, a comprehensive NGS analytic software package, OmicSoft Array Suite, and pre-processed cancer genomics data server, OmicSoft OncoLand, have been licensed. A new Dell PowerEdge R530 server and a new PSSC High Performance Computing (HPC) server have been installed to provide extensive computing support. A 96 TB Network Attached Drive (NAD) has also been installed for large-scale genomic dataset management and backup. Over the past 5 years, the Core provided essential computational and bioinformatics support for 37 Center members representing all three programs, provided support for 18 grant applications, and more than 70 cancer-related publications