INFORMATICS AND DATA MANAGEMENT

信息学和数据管理

• 批准号: 8378403
• 负责人: ANDREI L OSTERMAN
• 金额: $ 26.49万
• 依托单位: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-21 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8378403
• 关键词: Authorship; Bioinformatics; Biological; Biology; Biomedical Research; Budgets; Cancer Center; Cancer Center Support Grant; Chemicals; Communities; Computer Analysis; Computer Simulation; Consultations; Data; Data Analyses; Data Base Management; Databases; Development; Docking; Doctor of Philosophy; Evolution; Future; Gene Expression; Gene Proteins; Genomics; Genomics Shared Resource; Individual; Informatics; Institutes; Lead; Malignant Neoplasms; Microarray Analysis; NCI Center for Cancer Research; Paper; Participant; Pathway interactions; Process; Protein Analysis; Proteomics; Publishing; RNA Interference; Research; Research Personnel; Resource Informatics; Resource Sharing; Resources; Screening procedure; Services; Software Tools; Structural Models; Systems Biology; Talents; Techniques; Technology; Time; Training; Training Support; animal resource; anticancer research; base; cheminformatics; computer infrastructure; data integration; data management; experience; follow-up; functional genomics; high throughput analysis; improved; meetings; research and development; research study; response; small molecule libraries; tool; web site

The Informatics & Data Management Shared Resource provides advanced informatics support to the activities of the other Cancer Center Shared Resources, as well as informatics support and training to individual investigators in the Burnham Cancer Center. This Shared Resource is composed of two facilities: Bioinformatics and Cheminformatics. The Bioinformatics facility provides services to facilitate and expand the boundaries of Cancer Center research by providing a cutting-edge computational and bioinformatics support focusing on new data-intensive technologies, including (i) Analysis of Cancer Center investigator data generated in other Shared Resources; (ii) Support of other Cancer Center PI lab projects; (iii) Support of Cancer Center Shared Resource facility functions, and (iv) Bioinformatics classes and training for the entire Cancer Center community. The number of Cancer Center Pis using IDM services nearly tripled from 10 in the first year to 29 in the last year, and the number of Shared Resources receiving IDM support doubled. The Cheminformatics Facility provides informatics and database management for chemicals, chemical screening and related activities, as well as cheminformatics and computational support for SAR follow-up of hits, hit-to-lead optimization, structural modeling. In sllico screening. The IDM Shared Resource has contributed significantly to research in the Cancer Center. Critical contribution by IDM experts was acknowledged by co-authorship on more than 15 published papers during the last five years. Overall, the services in the Informatics and Data Management Shared Resource continue to evolve, due to the evolution of Cancer Research. A broad range of new tasks appeared in the menu of IDM services, including multidimensional analysis and interpretation of gene expression and proteomics data, in silico docking, development of project-oriented web-sites, etc. By going through these changes, adjusting and redefining itself, IDM developed into a mature resource of high and growing demand in the Cancer Center. Based on this experience as well as on the ever-accelerating progress of "omics" technologies, we project that the need in high-quality informatics support (such as provided by IDM) in Burnham's Cancer Center will keep increasing even faster than before. The IDM Shared Resource supplies the talent and expertise that will successfully be able to meet the anticipated future demands. Overall, $181,204 in CCSG support is requested for the first year, representing 40.4% of the total estimated annual operating budget of the Informatics & Data Management Shared Resource

信息学和数据管理共享资源为 其他癌症中心共享资源的活动，以及信息学支持和培训， 伯纳姆癌症中心的独立研究人员此共享资源由两个设施组成： 生物信息学和化学信息学。生物信息学设施提供服务， 通过提供尖端的计算和 生物信息学支持，重点是新的数据密集型技术，包括㈠癌症中心的分析 在其他共享资源中生成的研究者数据;（ii）支持其他癌症中心PI实验室项目; (iii)支持癌症中心共享资源设施功能，以及（iv）生物信息学课程和 为整个癌症中心社区提供培训。使用IDM服务的癌症中心PI数量 从第一年的10个增加到去年的29个，几乎增加了两倍， IDM支持增加了一倍。化学信息学设施提供信息学和数据库管理， 化学品、化学品筛选和相关活动，以及化学信息学和计算支持 用于命中的SAR跟踪，命中到铅优化，结构建模。在sllico筛选。IDM共享 资源为癌症中心的研究做出了重大贡献。IDM专家的重要贡献 在过去的五年中，在超过15篇发表的论文中被共同作者认可。总的来说， 信息学和数据管理共享资源中的服务将继续发展， 癌症研究的发展。IDM服务菜单中出现了一系列新任务，包括 基因表达和蛋白质组学数据的多维分析和解释，计算机对接， 通过这些变化，调整和重新定义 IDM本身已发展成为癌症中心高需求和不断增长的成熟资源。基于 这一经验以及不断加速的“组学”技术的进展，我们预测， 伯纳姆癌症中心需要高质量的信息学支持（如IDM提供的）， 比以前增长得更快。IDM共享资源提供的人才和专业知识， 能够满足预期的未来需求。 总体而言，第一年需要181 204美元的CCSG支助，占估计总额的40.4 信息学和数据管理共享资源的年度运营预算