Administrative Core

行政核心为这项U19研究提供全面领导， 百岁老人及其后代对阿尔茨海默病的抵抗力/复原力 它是3个核心和2个项目的通信枢纽，NIA科学 高级官员、单一IRB和OSMB（RADCO社区）的首席PI。核心 支持和鼓励RADCO社区之间的最佳互动，部分原因是 促进所有研究范围内、核心和项目特定的视频电话会议，并发布 会议记录和行动项目在该研究的内部融合为基础的网站。核心提供 出版物和演示文稿以及辅助研究委员会的领导， 协调一年三次的RADCO范围的视频会议，讨论在实现 目标是让每个人都了解其他人正在做什么和提供什么，特别是对初级 调查人员，有机会介绍他们的工作。在第二年和第四年，春季会议在 在Bethesda。行政核心还与NIA工作人员协调， 在OSMB。核心领导着更大的科学界的外联， 和维护RADCO的面向公众的网站和编排公开可用的 以及广受宣传的一年两次的科学研讨会。这些科学推广工作还包括 NIA的阿尔茨海默病相关数据共享政策的实施，通过与 表型分析和生物样本以及神经影像学核心，以执行质量控制， 并在3个月内将所有生成的数据传输到AD知识门户 可用于分析。所有这些责任都是成功实现 拟议研究的目标，并重申为以下具体目标。

The Administrative Core provides the overall leadership for this U19 study, Resistance/Resilience to Alzheimer's Disease in Centenarians and their Offspring (RADCO) and it acts as the communication hub for the 3 cores and 2 projects, NIA scientific officers, the Lead PI for the Single IRB and the OSMB (the RADCO community). The core supports and encourages optimal interactions amongst the RADCO community in part by facilitating all of the study-wide, core- and project-specific video conference calls and posting the minutes and action items on the Study's internal Confluence-based website. The Core provides the leadership of the Publications and Presentations and Ancillary Studies Committees and orchestrates triannual RADCO-wide video conference meetings to discuss progress in achieving the aims, to update everyone on what others are doing and provides, particularly for junior investigators, opportunities to present their work. In years 2 and 4, the Spring meeting is held in person in Bethesda. The Administrative Core also coordinates with NIA staff, biannual meetings with the OSMB. The Core leads the outreach to the greater scientific community with the creation and maintenance of the RADCO's public facing website and orchestration of publicly available and well-advertised biannual scientific workshops. These scientific outreach efforts also include implementation of NIA's Alzheimer's Disease-related data sharing policy by working with the Phenotyping and Biospecimen and the Neuroimaging Cores to perform quality control, curation and transfer of all generated data to the AD Knowledge Portal within 3 months of the data becoming available for analyses. All of these responsibilities are integral to successfully achieving the goals of the proposed research and they are reiterated as the following specific aims.