H2A Admin Core

肝细胞癌（HCC）是一种非常常见和致命的癌症在非洲，并与艾滋病毒感染者的生活 时间越长，HCC的负担可能会增加。在先前的研究中，我们的团队确定了慢性B型肝炎感染 C病毒（HBV、HCV）、HIV和曼氏血吸虫是HCC的独立危险因素。相比 对于美国，撒哈拉以南非洲的HCC发生在更年轻和更晚期的阶段， 个月建议在马凯雷雷大学的同事之间建立东非和西非伙伴关系， 乌干达、塞内加尔的法恩大学和约翰霍普金斯大学专注于艾滋病毒和肝细胞癌 非洲的肝癌（HCC）：H2 A联盟。建立在长期的合作研究，指导 在这两个国家的临床活动，我们的总体目标是减少肝癌的沉重负担， 撒哈拉非洲。我们提倡使用适当的药物治疗来研究癌症拦截策略 以中断或逆转这些导致HCC的感染的影响。行政和协调 核心（ACC）将为实施H2 A联盟的科学议程提供全面领导。使用 根据数十年国际研究合作的最佳实践，H2 A联盟提出了一个有效的 组织结构和强有力的领导，具有国际研究合作的记录。的 组织框架建立在以前的共同首席执行官之间持续的密切工作关系的基础上， 乌干达队和霍普金斯队，并欢迎塞内加尔队作为平等伙伴。ACC将建立 透明的结构，以支持严格的研究监督，有效的沟通，和有效的问题- 解决H2 A联盟有效地将ACC活动整合到一个密切互动的指导框架中， 委员会（SC）由总体共同领导人和项目/核心PI组成。对于每个项目或核心， 领导力代表了与来自每个站点的PI共享责任的公平伙伴关系。这种领导 核心还得到外部咨询小组（EAP）和社区咨询小组（CAP）的进一步支持， 与NCI计划领导和其他U 54联盟网站的协作链接。我们的综合影响 研究和能力发展活动将建立H2 A联盟， 东非和西非艾滋病毒和肝癌英才中心。

Hepatocellular carcinoma (HCC) is a very common and lethal cancer in Africa, and as patients with HIV live longer, the HCC burden may increase. In prior studies, our team identified chronic infection with hepatitis B and C viruses (HBV, HCV), HIV and Schistosomiasis mansoni as independent risk factors for HCC. Compared to the US, HCC in sub-Saharan Africa occurs at younger age and more advanced stage with survival of only months. Proposed is an East and West African partnership between colleagues at Makerere University in Uganda, Fann University in Senegal and Johns Hopkins University focused on HIV and hepatocellular carcinoma (HCC) in Africa: The H2A Consortium. Building on long-standing collaborative research, mentoring and clinical activities in both countries, our overarching goal is to reduce the heavy burden of HCC in sub- Saharan Africa. We advocate investigating cancer interception strategies using appropriate medical treatments to interrupt or reverse the impact of these HCC-causing infections. The Administrative and Coordinating Core (ACC) will provide overall leadership for implementing the scientific agenda of the H2A consortium. Using best practices from decades of international research collaboration, the H2A Consortium proposes an effective organizational structure and strong leadership with a track record of international research collaboration. The organizational framework builds upon the ongoing close working relationship between prior co-PIs from Uganda and Hopkins and welcomes the Senegalese team as equal partners. The ACC will establish transparent structures to support rigorous study oversight, effective communication, and efficient problem- solving. The H2A Consortium effectively integrates ACC activities within a closely interacting Steering Committee (SC) comprised of the Overall Co-Leaders and the Project /Core PIs. For each Project or Core, the leadership represents an equitable partnership with PIs from each site sharing responsibilities. This leadership nucleus is further supported by an External Advisory Panel (EAP) and a Community Advisory Panel (CAP), with collaborative links to NCI Program leadership and other U54 Consortia sites. The impact of our integrated research and capacity development activities will be establishment of the H2A Consortium as partnered Centers of Excellence on HIV and HCC in East and West Africa.