VERITY: Value and Evidence in Rheumatology using bioInformaTics, and advanced analYtics

项目总结 Verity的主要长期目标是：1)开发最先进的临床研究方法 与研究界相关的风湿病和肌肉骨骼疾病，2)提供 向研究界提供方法学和生物信息学援助，以及3)培训研究人员 通过课程、研讨会和指导，让社区学习最先进的方法。在最后一个周期中， Verity招募了一个由风湿病和MSK疾病研究人员组成的大型且不断增长的研究社区 参加课程、指导，并利用三个Verity核心的服务。总体而言， 该申请描述了：Verity蓬勃发展的研究社区的进展和未来方向； Verity如何开发和提供课程以响应研究社区的需求，特别是 在COVID大流行期间；对受训人员和初级教员的未来课程和指导计划；以及 提供的服务以及方法学核心和生物信息学核心的组织。在上一次 周期，Verity开发了一个多元化的研究社区，其中包括许多初级教职员工和实习生， 大量的儿科风湿病医生，以及越来越多的MSK调查人员。这些研究人员 代表了从事NIAMS重点主题的临床研究人员的巨大多样性。此外, 庞大的调查小组帮助为核心提供源源不断的活动和资源。 在BWH CCCR的前一个周期中，Verity帮助制作了160篇已被引用的原创文章1287篇 泰晤士报。这些原创文章发表在影响力很大的期刊上。Verity研究社区已经 在过去4年多的时间里，我成功地提交了109份赠款申请，总额为400,073,225美元 在年度直接研究收入中。这三个核心非常富有成效，学到了很多。 关于与研究社区有效合作的问题。拟议的目标建立在以往成功经验的基础上，包括： 一项增强的充实计划增加了对风湿病研究人员的关注；一种方法论 确保方法严谨的核心，同时将行为理论和经济学纳入研究 重点关注种族和少数族裔；以及生物信息学核心，提供生物信息支持，以更好地 表型患者队列，允许研究健康的社会决定因素。

PROJECT SUMMARY The overarching long-term aims of VERITY are: 1) to develop state-of-the-art methods for clinical research in rheumatology and musculoskeletal diseases that are relevant for the Research Community, 2) to deliver methodologic and bioinformatic assistance to the Research Community, and 3) to train the Research Community in state-of-the-art methods through courses, seminars, and mentoring. During the last cycle, VERITY recruited a large and growing Research Community of rheumatic and MSK disease investigators who participate in courses, mentoring, and utilize the services of the three VERITY Cores. The Overall Section of the application describes: the progress and future directions for VERITY’s burgeoning Research Community; how VERITY has developed and delivered courses to respond to the Research Community’s needs, especially during the COVID pandemic; plans for future courses and mentoring of trainees and junior faculty; and the services offered and organization of the Methodology Core and the Bioinformatics Core. During the previous cycle, VERITY developed a diverse Research Community that has included many junior faculty and trainees, a good number of pediatric rheumatologists, and an increasing group of MSK investigators. These researchers represent the tremendous diversity of clinical investigators engaged with NIAMS-focused topics. In addition, the large group of investigators helps provide the Cores with a steady stream of activity and resources. During the prior cycle of the BWH CCCR, VERITY helped produce 160 original articles already cited 1,287 times. These original articles appeared in high impact journals. The VERITY Research Community has been successful with 109 grant submissions during the last 4+ years, tabulating a total of $40,073,225 in annual direct research revenues. The three Cores have been extremely productive and learned much about working effectively with the Research Community. The proposed aims build on the prior successes with: an enhanced Enrichment Program increasing the focus on URiM researchers in rheumatology; a Methodology Core that ensures methodologic rigor while incorporating behavioral theory and economics into studies focused on racial and ethnic minorities; and a Bioinformatics Core that provides bioinformatic support to better phenotype patient cohorts, allowing for studies of social determinants of health.