NIAID DCR OPERATIONAL TASK ORDERCOVID FUNDING SUPPORTS THE NIAID DCR COVID WEBSITE AND THE VARIANT TESTING SAVE PROGRAM FOR VARIANT TESTING.

CoVID SARS-CoV-2评估病毒进化(SAVE)变异测试为分析新冠肺炎治疗和观察性试验中收集的样本的SARS-CoV-2基因组序列提供支持，以确定可能影响诊断、治疗、疫苗效力和疾病严重程度的基因变异。将在NIAID特别项目中对从观察性研究和诊断目的收集的样本进行额外的基因组测序。这将扩大对SARS-CoV-2变种传播的了解。COVID SAVE为分析SARS-CoV-2变异株在体外中和试验中的影响提供了支持。此外，COVID SAVE变异检测可以分析SARS-CoV-2的演变，并识别未来可能对公共卫生造成影响的变异

COVID SARS-CoV-2 Assessment Viral Evolution (SAVE) variant testing provides support for analysis of SARS-CoV-2 genome sequences from specimens collected in COVID-19 therapeutic and observational trials for genetic variants that could impact diagnostics, therapeutics, vaccine efficacy, and disease severity. Additional genome sequencing will be done at NIAID Special Projects on samples collected from observational studies and for diagnostic purposes. This will broaden the understanding of the circulation of SARS-CoV-2 variants. COVID SAVE provides support for the analysis of the impact of SARS-CoV-2 variants in vitro neutralization assays. Additionally, COVID SAVE variant testing allows analysis of the evolution of SARS-CoV-2 and identification of future variants with potential public health impacts