Methods and Strategies for the Concise Synthesis of Complex Alkaloid Natural Products - Equipment Supplement

请求摘要。我们正在申请购买微波合成器的资金， Biotage Initiator+与Robot Eight配合使用，实现复杂有机物的精确高效合成 分子。基于微波的合成代表了用于化学合成的已建立的方法，特别是 对于需要高温的反应，由于其能够提供较高的产率，较少的副产物， 和更短的反应时间。这台反应器将使我们能够进行复杂的有机合成， 由安全的微波源产生的强烈、均匀的热量的受控条件。此外，自动进样器 助剂的加入将有利于反应条件的优化和更广泛的反应机理的探索。 反应底物总的来说，反应堆将大大提高我们完成所概述工作的能力 在我们的资助下，“复杂吲哚生物碱简明合成的新方法和策略”（NIH- NIGMS 5R01GM144663-02）。

Summary of the Request. We are requesting funds for the purchase of a microwave synthesizer, the Biotage Initiator+ with Robot Eight, to enable the precise and efficient synthesis of complex organic molecules. Microwave-based synthesis represents an established method for chemical synthesis, especially for reactions that require high temperatures, due to its ability to provide higher yields, fewer side products, and shorter reaction times. This reactor will enable us to perform complex organic syntheses under controlled conditions of intense, even heat from a safe microwave source. Additionally, the auto-sampler accessory will facilitate the optimization of reaction conditions and the exploration of a wider range of reaction substrates. Overall, the reactor will significantly enhance our ability to complete the work outlined in our grant, “New Methods and Strategies for the Concise Synthesis of Complex Indole Alkaloids” (NIH- NIGMS 5R01GM144663-02).