Administrative Core

偏头痛是最常见的原发性头痛疾病之一，影响四分之一的美国家庭。这个复杂 神经障碍部分由三叉神经躯体感觉的改变介导，三叉神经躯体感觉的改变表现为头/发- 坐骨神经痛和/或三叉神经异常性疼痛。偏头痛的有效治疗方法仍然有限，我们对偏头痛的认识 人三叉神经系统在基线和偏头痛条件下是稀疏的。响应RFA-NS-22 - 018，HEAL 计划：人类疼痛相关基因和细胞的发现和功能评价，我们建议 成立宾州人类精确疼痛中心（Penn HPPC），以阐明分子，细胞，表观遗传， 在基线和偏头痛条件下的人三叉神经节（TG）感觉神经元的生理概况。 Penn HPPC将由具有多学科专业知识的Penn和国际研究人员组成。的 PI，两个MPI和两个co-I目前正在合作进行人类背根的单细胞体深层RNA测序 神经节（DRG）项目，为该应用奠定了坚实的基础。Penn HPPC将包含三个 核心，并执行三个项目。其中，行政核心将作为唯一的组织机构， 宾夕法尼亚大学HPPC的管理实体，它将支持和联合不同核心的研究活动 通过提供领导、资源和监督来支持和研究项目。行政核心也将- 与其他U19中心和NIH HEAL Initiative PRECISION Human Pain网络实体进行沟通，以确保 促进整体协同成功。行政核心将由PI，罗博士和三个 MPIs，李博士，Olausson和吴，并由财务和行政协调员支持。具体而言是 管理核心将促进宾夕法尼亚大学HPPC之间的沟通和资源、数据和想法的共享 调查员，支持和加强对初级同事的培训和指导，确保健全的财务和法规， 内部监督，协调外部监督，确保及时实现里程碑，并传播 将研究结果提交给NIH HEAL Initiative PRECISION Human Pain网络实体和科学界， 适时简而言之，宾夕法尼亚州HPPC行政核心将提供所有必要的行政支持 确保达到宾夕法尼亚州HPPC的科学目标和里程碑。

Migraine, one of the most common primary headache disorders, affects 1 in 4 US households. This complex neurologic disorder is mediated in part by alterations in trigeminal somatosensation, which manifests as head/fa- cial pain and/or trigeminal allodynia. Effective treatments for migraine are still limited, and our knowledge about human trigeminal system at baseline and migraine conditions are sparse. In response to RFA-NS-22-018, HEAL Initiative: Discovery and Functional Evaluation of Human Pain-associated Genes & Cells, we propose to form the Penn Human Precision Pain Center (Penn HPPC) to elucidate molecular, cellular, epigenetic, and physiological profiles of human trigeminal ganglion (TG) sensory neurons at baseline and migraine conditions. The Penn HPPC will be composed of Penn and international investigators with multidisciplinary expertise. The PI, two MPIs, and two co-Is are currently collaborating on a single-soma deep RNA-seq of human dorsal root ganglion (DRG) project, which form a strong foundation for this application. The Penn HPPC will contain three cores and perform three projects. Among them, the administrative core will serve as the sole organizational and administrative entity for the Penn HPPC, which will support and unite research activities of different cores and research projects by providing leadership, resources, and oversight. The administrative core will also com- municate with other U19 centers and the NIH HEAL Initiative PRECISION Human Pain network entities to ensure and promote the overall synergy and success. The administrative core will be led by the PI, Dr. Luo, and three MPIs, Drs. Li, Olausson, and Wu, and supported by financial and administrative coordinators. Specifically, the administrative core will foster communication and sharing of resources, data, and ideas among the Penn HPPC investigators, support and enhance training and mentoring of junior colleagues, ensure sound financial and reg- ulatory oversight, coordinate external oversight and ensure timely progression toward milestones, and dissemi- nate findings to the NIH HEAL Initiative PRECISION Human Pain network entities and scientific community in a timely manner. In short, the Penn HPPC administrative Core will provide all necessary administrative support to ensure that the scientific goals and milestones of the Penn HPPC are met.