Hawaii Pacific Islands Mammography Registry

父项目摘要/摘要 尽管最近在早期发现和治疗方面取得了进展，但乳腺癌仍然是发病率的主要原因。 和死亡率。夏威夷土著妇女的乳腺癌发病率在夏威夷最高，尽管她们 有利的繁殖模式。日裔美国女性现在经历的乳腺癌风险与 此外，亚裔美国人的晚期乳腺癌发病率要高得多 与美国大陆相比，夏威夷和太平洋地区的女性比例为15%，而美国大陆为9%。侵入性的绝对风险 这些美国人群中的癌症和晚期癌症尚不清楚。我们的长期目标是 开发准确和有效的乳腺癌风险生物标记物，有助于筛查 具有不同乳腺癌风险特征的亚洲群体，到目前为止，他们在乳房中没有得到很好的代表 癌症队列和临床试验。夏威夷太平洋岛屿乳房摄影登记处将成为 来源以确定和验证该地区不同种族的新图像生物标记物 风险因素简介包括夏威夷原住民、日本人、菲律宾人、中国人和其他种族。 结合旧金山乳房X光照相登记处和HIPIMR队列，我们将拥有统计能力 描述亚洲人群中浸润性癌症和晚期癌症的风险。我们的中心假设是 乳腺癌危险因素和形象因素及其在不同人群中的患病率不同 在太平洋地区(夏威夷、关岛、美属萨摩亚)和亚洲族裔群体高度集中。 美国本土与非西班牙裔白人、非西班牙裔黑人和西班牙裔女性的比较。我们计划测试一下 假设使用风险因素概况和下一代乳房成分和质地特征 美国人口中增长最快的亚裔群体和NHPI种族群体将改善癌症 风险预测。与非西班牙裔白人女性相比，我们的具体目标是：1.检查临床风险 乳腺癌患者中浸润性乳腺癌和晚期乳腺癌的影响因素及其相关性 按亚洲人(日本人、菲律宾人、中国人)和夏威夷太平洋岛民(AANHPI)血统进行筛查，2. 从2D和3D乳房X光检查中确定下一代乳房成像特征，包括体积测量 乳腺密度、钙化、肿块、纹理特征及其与侵袭性和进展性的关系 AANHPI女性乳腺癌，使用先进的人工智能和机器学习方法，3. 确定与侵袭性和晚期乳房相关的临床风险因素和影像因素的组合 AANHPI妇女的癌症风险。这项研究解决了准确识别已定义的 AANHPI人群的临床和放射危险因素及其与乳腺癌风险的关系有待改善 这些女性的结果。

PARENT PROJECT SUMMARY / ABSTRACT Despite recent advances in early detection and treatment, breast cancer remains a major cause of morbidity and mortality. Native Hawaiian women have the highest breast cancer incidence in Hawaii despite their favorable reproductive patterns. Japanese American women now experience the same breast cancer risk as non-Hispanic White women Further, advanced breast cancer rates are considerably higher in Asian American Women in Hawaii and the Pacific compared to the US mainland, 15% versus 9%. The absolute risk of invasive cancer and advanced cancer in these groups of the US population is not known. Our long-term goal is to develop accurate and validated breast cancer risk biomarkers that can contribute to screening strategies for Asian groups with diverse breast cancer risk profiles who to date have not been well represented in breast cancer cohorts and clinical trials. The Hawaii Pacific Islands Mammography Registry (HIPIMR) will be the source to identify and validate novel image biomarkers for the diverse ethnic groups of this region with varying risk factor profiles including Native Hawaiians, Japanese, Filipino, Chinese, and other ethnic groups. Combining San Francisco Mammography Registry and HIPIMR cohorts will give us the statistical power to describe the risk of invasive and advanced cancer in Asian groups. Our central hypothesis is that standard breast cancer risk factors and image factors and their prevalence are different in the diverse populations found in high concentrations in the Pacific (Hawaii, Guam, American Samoa) and Asian ethnic groups in the mainland US compared to non-Hispanic White, non-Hispanic Black and Hispanic women. We plan to test the hypothesis that using risk factor profiles and next-generation breast composition and texture features across Asian groups, the fastest growing segment of the US population,9 and NHPI ethnic groups will improve cancer risk prediction. Our specific aims are as compared to non-Hispanic White women: 1. Examine clinical risk factors and their association with invasive and advanced breast cancer in women undergoing breast cancer screening by Asian (Japanese, Filipino, Chinese) and Native Hawaiian Pacific Islander (AANHPI) ancestry, 2. Identify next-generation breast imaging characteristics from 2D and 3D mammography, including volumetric breast density, calcifications, masses, texture features, and their association with invasive and advanced breast cancer for AANHPI women, using advanced artificial intelligence and machine learning approaches, 3. Identify the combination of clinical risk factors and image factors associated with invasive and advanced breast cancer risk among AANHPI women. This study addresses the need for accurate identification of defined clinical and radiomic risk factors among AANHPI populations and their relation to breast cancer risk to improve outcomes for these women.