The Ancestral Populations Network Phenotypic Harmonization Working Group Administrative Supplement: 2/3 Genomics of Schizophrenia in the South African Xhosa

项目总结 该项目实现了祖传人口网络(APN；PAR-20-026和PAR-20- 027)，即促进亚太国家联盟成员之间的计量和数据分析协调工作，以加强 严密性和可重复性，并为网络成员和科学界提供资源。通过一个 APN成员的共识过程、快感缺乏、认知、强迫症状、 自杀和歧视/耻辱被选为正在进行的研究的协调对象。这些 统一的衡量标准将在大约27,500名代表亚洲、拉丁语的个人中收集 美洲人和非洲人的祖先横跨15个国家。 APN与本补编之间的摘要和联系 祖传人口网络(APN)是由国家精神卫生研究所(PAR-20- 026和PAR-20-027)，首要目标是：(A)加快精神疾病的基因发现 非欧洲血统的队列，(B)促进全球心理健康发现和公平，以及(C)促进 跨成员的衡量和数据分析协调努力，以增强严谨性和可重复性，并 为网络成员和科学界生成资源。本副刊将实施 快感缺乏、认知、强迫症状、自杀倾向和 在APN内正在进行的研究中的歧视/污名。这些协调一致的措施将被收集 估计有27,500个人代表着亚洲、拉丁美洲和非洲的祖先 超过15个国家。

PROJECT SUMMARY This project actualizes a primary goal of the Ancestral Populations Network (APN; PAR-20-026 and PAR-20- 027), namely to facilitate measurement and data analytic harmonization efforts across APN members to enhance rigor and reproducibility and generate a resource for network members and the scientific community. Through a consensus process of APN members, measures of anhedonia, cognition, obsessive-compulsive symptoms, suicidality, and discrimination/stigma were selected for harmonization across ongoing studies. These harmonized measures will be collected across an estimated 27,500 individuals representing Asian, Latin American, and African ancestries spanning over 15 countries. SUMMARY AND CONNECTION BETWEEN THE APN AND THIS SUPPLEMENT The Ancestral Populations Network (APN) was established by the National Institutes of Mental Health (PAR-20- 026 and PAR-20-027) with overarching goals of (a) accelerating genetic discovery for psychiatric disorders in cohorts of non-European ancestry, (b) advancing global mental health discovery and equity, and (c) facilitating measure and data analytic harmonization efforts across members to enhance rigor and reproducibility and generate a resource for network members and the scientific community. This supplement will implement validated measures of anhedonia, cognition, obsessive-compulsive symptoms, suicidality, and discrimination/stigma across ongoing studies within the APN. These harmonized measures will be collected across an estimated 27,500 individuals representing Asian, Latin American, and African ancestries spanning over 15 countries.