Interdisciplinary Clinical Advances and Research Excellence in TMDs (ICARE 4 TMDs) Collaborative

项目总结/摘要 我们的跨学科临床进展和卓越研究的长期目标是颞下颌关节 疾病（ICARE 4 TMD）协作是为了提供一个强大的框架， 全面的国家跨学科的探索，以TMD和共病条件。TMD是一种 涉及咀嚼肌、颞下颌关节及相关疾病的一系列异质性疾病 结构，影响美国人口的5%至10%，每年的医疗费用约为40亿美元。大幅 部分患者还存在全身性合并症，如头痛和纤维肌痛。因为 由于其发病机制尚不清楚，其诊断和治疗仍无特异性。因此，委员会认为， 患者经常忍受使人衰弱的疼痛和他们不能承担基本功能，如进食和 言语影响生活质量并造成心理困扰。确定导致或 易患TMD的个体将能够早期识别并指导合理治疗的设计， 实现这一目标需要跨越传统界限的研究和临床应用。边界 这些限制了对TMD的理解和治疗的进展， 科学和临床应用，以及几个科学学科之间-从肌肉骨骼到疼痛 从科学到再生医学为了解决知识和临床护理方面的这些主要差距，ICARE 4 TMD 合作将建立研究优先事项、资金和劳动力发展机制， 有意地将这些科学和病人护理领域结合起来。鉴于这一主要目标，我们制定了一个 一个国家合作的健全的概念模型，将进一步完善，详细和结构化， 规划阶段。这项规划赠款的结果是建立一个反应迅速的行政和 业务结构;聘请学者和导师利用他们的专业知识进行综合研究， 劳动力发展;确定跨学科项目和职业资助的标准和协议 发展方案。这些目标将通过以下方式实现：（1）规划实施综合 在疼痛和神经病学、肌肉骨骼疾病、再生医学、 和生物标志物;以及（2）绘制并启动一个强大而创新的劳动力发展计划， 具有整合新技术和方法能力的多元化多方面学者和临床医生 加速发现和提供个性化的跨学科患者护理。本申请 利用内部多机构的智力人才和受资助调查员/导师的专业知识， 在外地，建立了基础设施和核心设施以及培训方案。该应用程序高度 响应FOA，因为它真正涵盖，跨学科和综合的方法来解剖 TMDs用于改善和有针对性的患者护理，因为它提供了一个引人注目的前瞻性框架 一个全面而充满活力的TMD协作。

Project Summary / Abstract The long-term goal of our Interdisciplinary Clinical Advances and Research Excellence in Temporomandibular Disorders (ICARE 4 TMDs) Collaborative is to provide a robust framework to undertake a cohesive and comprehensive national interdisciplinary exploration into TMDs and comorbid conditions. TMDs are a constellation of heterogenous disorders involving the masticatory musculature, the TMJ, and associated structures, afflicting 5 to 10% of US population with annual healthcare costs of ~$4 billion. A substantial proportion of patients also present with systemic comorbidities such as headaches and fibromyalgia. Because of their unknown etiopathogenesis, the diagnosis and therapies for TMDs remain non-specific. Consequently, patients often tolerate debilitating pain and their inability to undertake essential functions such as eating and speech impacts quality of life and contributes to psychological distress. Identifying factors that cause or predispose individuals to TMDs will enable early recognition and guide the design of rational therapies, but achieving this goal requires research and clinical applications across traditional boundaries. The boundaries that limit progress in understanding or treating TMDs encompass the translational gap between discovery science and clinical applications, and between the several scientific disciplines - from musculoskeletal to pain science to regenerative medicine. To address these major gaps in knowledge and clinical care, ICARE 4 TMDs Collaborative will establish research priorities and funding and workforce development mechanisms that intentionally integrate these scientific and patient care domains. Given this primary goal, we have developed a sound conceptual model for a national Collaborative that will be further refined, detailed, and structured during the planning phase. The outcome of this planning grant is to establish a responsive administrative and operational structure; engage scholars and mentors to utilize their expertise for integrated research and workforce development; and define criteria and protocols for funding of interdisciplinary projects and career development programs. These objectives will be achieved by (1) planning the implementation of integrated bridging science from basic to clinical in pain and neurology, musculoskeletal disorders, regenerative medicine, and biomarkers; and (2) map and launch a robust and innovative workforce development program for training diverse multi-faceted scholars and clinicians with capabilities of integrating novel technologies and approaches towards accelerating discoveries and delivery of individualized interdisciplinary patient care. This application leverages multi-institutional intellectual talent and expertise of funded investigators / mentors from within and outside the field, established infrastructure and core facilities, and training programs. The application is highly responsive to the FOA due to its truly encompassing, interdisciplinary and integrated approach to dissecting TMDs for improved and targeted patient care, and because it provides a compelling forward-looking framework for a comprehensive and vibrant TMD Collaborative.