Role of distinctive cortical motor maps for hand muscles for recovery post stroke

项目摘要/摘要 家长资助(R01 HD094731)的目标是确定是否将TheraBraclet与手工作业相结合 对于中风后手功能的充分恢复，练习优于单纯的手作业练习 动力研究。父母的资助旨在确定TheraBraclet对手功能恢复的影响， 感觉运动抓握控制，以及皮质感觉运动网络内的神经通信。建议数 多样性补充与作为补充的家长奖的范围和批准的目标很好地一致 目的是研究神经可塑性对手部肌肉独特的皮质运动图的可能贡献 为了运动恢复。具体地说，该补充文件旨在确定康复干预对 经颅磁刺激测量手部肌肉运动图的空间区分性 (TMS)，并确定运动地图改变和运动恢复之间的关系。本副刊 预计研究将为恢复细小运动控制的机制提供新的见解 划水后的手。这一新知识将对开发新的康复疗法至关重要 这有助于实现手运动恢复所需的皮质神经可塑性。最重要的是，这个奖项 将培养代表不足的少数族裔候选人(阿里安娜·阿尔斯顿女士)的神经科学博士研究生涯。 培训活动的重点将是为奥尔斯顿女士开发新的研究技能，以执行附录 研究并开始她的研究生涯。具体地说，阿尔斯顿女士将(1)增强她的神经科学知识 应用于神经康复研究，(2)熟练收集、分析和解释TMS 用于皮质脊髓神经肌肉控制的运动图，以及(3)开发一个成功的博士项目申请。 因此，这一补充奖励将有助于加强生物医学劳动力的多样性，因为只有7% 科学和工程学科的博士学位获得者中有一半是非洲裔美国人，而非洲人 根据美国国家科学基金会的报告，18-74岁的美国人占美国总人口的12%。

PROJECT SUMMARY / ABSTRACT The objective of the parent grant (R01 HD094731) is to determine if combining TheraBracelet with hand task practice is superior to hand task practice alone for recovery of hand function post-stroke in an adequately powered study. The parent grant aims to determine the effect of TheraBracelet on hand functional recovery, sensorimotor grip control, and neural communication within the cortical sensorimotor network. The proposed diversity supplement aligns nicely with the scope and approved aims of the parent award as the supplement aims to investigate neuroplasticity toward distinctive cortical motor maps for hand muscles that may contribute to motor recovery. Specifically, the supplement aims to determine the effect of rehabilitation intervention on spatial distinctiveness among motor maps of hand muscles as measured using transcranial magnetic stimulation (TMS) and determine the relationship between motor map changes and motor recovery. This supplement research is expected to inform the new insights for the mechanism for recovery of the fine motor control of the hand following stroke. This new knowledge will be critical for the development of novel rehabilitation treatments that facilitate the cortical neuroplasticity necessary to achieve hand motor recovery. Most importantly, this award will foster the underrepresented minority candidate (Ms. Arianna Alston) for a PhD neuroscience research career. The training activities will focus on developing new research skills for Ms. Alston to perform the supplement research and begin her research career. Specifically, Ms. Alston will (1) enhance her knowledge of neuroscience applied to neurorehabilitation research, (2) develop proficiency in collecting, analyzing, and interpreting TMS motor maps for corticospinal neuromuscular control, and (3) develop a successful application for a PhD program. Therefore, this supplement award will contribute to enhancing diversity in the biomedical workforce, as only 7% of doctoral degree recipients in science and engineering disciplines were African American, whereas African Americans make up 12% of the total US population between the ages of 18-74 according to NSF report.