Brain networks for specific motor control impairments following stroke

项目概要/摘要 母公司补助金（R 01 HD 094731）的目的是确定TheraBracelet与手部任务相结合是否 对于中风后手功能的恢复，练习上级优于单独的手任务练习， 动力研究母基金Aim 2专注于确定TheraBracelet对感觉运动抓握的影响 皮层感觉运动网络内的控制和神经通信。这种多样性补充将提供 对中风幸存者不同抓握控制障碍的神经机制的新认识。 具体来说，这种多样性补充的目的是确定负责前馈的大脑网络 和反馈运动控制。据推测，前馈电机控制将是 在运动计划阶段，反馈运动与运动皮层内的连接有关， 在运动执行期间，控制将与感觉区域和运动区域之间的连接相关联 相位这项研究有望揭示负责前馈的特定大脑网络， 上肢的反馈运动控制。创新在于研究大脑网络和运动控制 一起这一新的知识将是至关重要的发展个性化中风后康复 范式：该范式可能涉及首先评估个体运动控制过程以确定特定的 负责临床运动障碍的运动控制，然后设计个性化治疗， 针对负责受损运动控制的特定大脑网络。最重要的是，该奖项将 培养代表性不足的少数民族候选人（亚当贝克先生）作为职业DPT/博士研究员。培训 活动将侧重于发展新的研究技能，贝克先生进行补充研究， 开始他的研究生涯具体而言，贝克先生将（1）提高对 神经康复研究领域，（2）掌握量化，分析和解释前馈的能力 并反馈运动控制生物力学数据和基于脑电的脑网络数据，以及（3）开发成功的 申请DPT/PhD课程。因此，这一补充奖将有助于提高多样性， 生物医学劳动力，因为在176万人中只有2,000名女性是美洲印第安人或阿拉斯加土著人 根据NSF报告，拥有博士学位的受雇科学家和工程师（由于 可靠性）。

PROJECT SUMMARY / ABSTRACT The objective of the parent grant (R01 HD094731) is to determine if combining TheraBracelet with hand task practice is superior to hand task practice alone for recovery of hand function post-stroke in an adequately powered study. The parent grant Aim 2 focuses on determining the effect of TheraBracelet on sensorimotor grip control and neural communication within the cortical sensorimotor network. This diversity supplement will provide a new insight into the neural mechanisms for different grip control impairments among individual stroke survivors. Specifically, the aim of this diversity supplement is to determine the brain network responsible for the feedforward and feedback motor control in stroke survivors. It is hypothesized that feedforward motor control will be associated with connectivity within the motor cortices during the motor planning phase, while feedback motor control will be associated with connectivity between the sensory and motor regions during the motor execution phase. This research is expected to unveil the specific brain network responsible for the feedforward and feedback motor control of the upper extremity. Innovation is in investigating brain networks and motor controls together. This new knowledge will be critical for the development of a personalized post-stroke rehabilitation paradigm: This paradigm may involve first assessing individual motor control processes to determine the specific motor control that is responsible for clinical motor impairment, followed by design of a personalized treatment to target the specific brain network responsible for the impaired motor control. Most importantly, this award will foster the underrepresented minority candidate (Mr. Adam Baker) as a career DPT/PhD researcher. The training activities will focus on developing new research skills for Mr. Baker to perform the supplement research and begin his research career. Specifically, Mr. Baker will (1) enhance the overall knowledge of the neurorehabilitation research field, (2) acquire proficiency in quantifying, analyzing, and interpreting feedforward and feedback motor control biomechanics data and EEG-based brain network data, and (3) develop a successful application for a DPT/PhD program. Therefore, this supplement award will contribute to enhancing diversity in the biomedical workforce, as only 2,000 females are American Indian or Alaskan Native out of 1.76 million employed scientists and engineers holding doctorates according to NSF report (data suppressed for males due to reliability).