MCSP TORFP NO. NIH-NINDS-21-01: FLORIO (ANAGIN) - BASE EC (STROKE)

承包商在履行本合同项下的工作时， 任务单应提供支持药物化学的全方位服务设施和工作人员 从探索性化学阶段开始的发现计划，以开发结构活动 相关性（SAR）分析和设计、合成、体外吸收、分布、代谢， 排泄和毒理学（ADMET），计算化学/计算机辅助药物发现 （CADD）和仓储和运输的复合物流，以支持贡献者Florio （Anagin）开发一种有效治疗中风的新疗法。这将通过推进 利用其测定法测定其小分子杂环起始化合物的SAR/SPR， 体外ADMET以鉴定靶酶的新型选择性抑制剂， 缺血性中风本药物化学支持计划（MCSP）任务订单的范围 应为性能领域2：药物化学支持下的药物化学服务 支持NIH、NINDS及其贡献者支持的临床前药物发现工作 (as在《父工作说明书》中概述）。

The Contractor, in performance of work under this task order shall provide a full-service facility and staff who would support a medicinal chemistry discovery program beginning at the Exploratory Chemistry phase to develop structure activity relationship (SAR) analysis and design, synthesis, in vitro absorption, distribution, metabolism, excretion and toxicology (ADMET), computational chemistry/Computer Aided Drug Discovery (CADD) and compound logistics of storage and shipping to support the Contributor Florio (Anagin) to develop a novel therapeutic effective in stroke. This will be achieved by advancing the SAR/SPR of their small molecule heterocyclic starting compound utilizing their assays and in vitro ADMET to identify novel, selective inhibitors of the target enzyme that are directed at ischemic stroke. The scope of this Medicinal Chemistry Support Program (MCSP) task order shall be medicinal chemistry services under Performance Area 2: Medicinal Chemistry Support in support of preclinical drug discovery efforts supported by NIH, NINDS and its Contributors (as outlined in the Parent SOW).