Mechanism of pulmonary endothelial cell heterogeneity and its role in disease

项目摘要/摘要 候选人：利桑德拉·维埃利斯博士是一位在血管生物学和肺发育方面接受过广泛培训的内科医生。 她是MD安德森癌症中心的博士后研究员，试图了解血管是如何发育的 以及这个过程在疾病中是如何受到影响的。她刚刚发表了她的第一篇论文，也是第一作者 发育细胞。 职业发展：Vila Ellis博士的导师包括陈继超博士，他是一位成功的科学家，研究 和伯顿·迪基博士，一位有30多年研究经验的内科医生 肺脏的经验。此外，Vila Ellis博士还将得到该领域许多合作者的支持 作为指导委员会，以确保她达到这项提案的预期里程碑，并保证 顺利过渡到独立职业生涯。 研究：Vila Ellis博士的工作表明，血管内皮生长因子A(Vegfa)指定了一种新的 肺内皮细胞的数量。这些细胞在转录和形态上是不同的，并且在 肺泡间隙异常增大，使人联想到支气管肺发育不良.在 未来，Vila Ellis博士将研究这种指定过程是如何发生的，以及这些新细胞在肺中扮演什么角色 疾病。 总之，这项建议将解决肺内皮细胞异质性的机制，并有助于 确立肺内皮细胞在发育性疾病起源中的关键成分。

PROJECT SUMMARY/ABSTRACT Candidate: Dr. Lisandra Via Ellis is a physician with extensive training in vascular biology and lung development. She is a postdoctoral fellow at MD Anderson Cancer Center seeking to understand how blood vessels develop in the lung and how this process is affected in disease. She just published her first, first-author paper in Developmental Cell. Career development: Dr. Vila Ellis' mentors include Dr. Jichao Chen, a successful scientist who studies developmental biology in the mouse lung, and Dr. Burton Dickey, a physician who has over 30 years of research experience in the lung. Additionally, Dr. Vila Ellis will have the support of many collaborators in the field, as well as a mentoring committee to ensure she meets the expected milestones of this proposal, and guarantee a smooth transition to an independent career. Research: Dr. Vila Ellis' work has shown that Vascular endothelial growth factor A (Vegfa) specifies a novel population of endothelial cells in the lung. These cells are transcriptionally and morphologically distinct, and in their absence the alveolar space is aberrantly enlarged, reminiscent of bronchopulmonary dysplasia. In the future, Dr. Vila Ellis will study how this specification process happens and what role these new cells play in lung disease. In summary, this proposal will address the mechanisms of pulmonary endothelial cell heterogeneity and help establish the lung endothelium as a key component in the origin of developmental diseases.