A New Paradigm for Treating Functional Abdominal Pain Disorders in Children

项目摘要 约翰·M·霍利尔，医学博士，委员会认证的儿科胃肠病专家，贝勒学院助理教授 寻求获得基本技能和为独立职业生涯提供指导的研究经验的医学博士 作为一名利用卫生技术的儿科临床研究人员。许多健康状况因贫困而受到影响。 坚持用药，不明智的健康行为，以及获得医疗保健的机会很少。候选人的职业生涯 目标是通过利用当前(例如移动)和未来技术的潜力来克服这些障碍 作为完成这些努力的工具。功能性腹痛障碍(FAPD)影响高达15%的学校- 在全世界范围内，儿童(和成人)年龄较大，并与显著的发病率和医疗费用有关。向上 有FAPDS的儿童中，有60%的人会出现与成人类似的情况。许多受影响的儿童患有 心理上的困扰，如焦虑和抑郁。对这些疾病最有效的治疗方法 (心理干预)对大多数FAPDS儿童来说仍然遥不可及。申请人建议： 完善他的创新移动应用程序(App)原型，旨在远程提供录音指导 应用公认的技术开发对儿童FAPDS患者的成像治疗(ARGIT App) 技巧。申请人对患者和提供者采用了以用户为中心的设计方法 开发精致的ARGIT应用程序(特定目标1)。这一延期将集中在赠款的最后两个具体 目的：2)进行随机、等待名单对照试验，比较治疗和引导成像疗法 (GIT)与常规护理相比，FAPDS儿童。GIT会话将通过精炼的 超过八周的ARGIT应用程序。3)评估改进后的ARGIT App在受影响儿童中的接受度 和他们的照顾者通过定性访谈。奥利耶博士组建了一个多学科团队， 尊敬的NIH资助的导师和合作者，他们在移动健康应用程序开发方面拥有不同的专业知识， 临床试验方法论、定性研究方法和健康行为改变专家。此外, 候选人将通过研讨会和会议获得额外的培训，以增加他的知识 慢性疼痛基础，基于社区的参与性研究，以非药理学技术为基础 疼痛治疗，以及支持拨款撰写和研究团队的专业发展 管理层。这笔赠款提供的科学培训和教育机会将导致 出版物、科学数据和经验，将增强候选人的知识基金，以确保 作为一名专门从事健康技术的内科科学家，美国国立卫生研究院独立资助。

Project Abstract John M. Hollier, MD, a board-certified pediatric gastroenterologist, is an Assistant Professor at Baylor College of Medicine who seeks to obtain essential skills and mentored research experience for an independent career as a pediatric clinical researcher utilizing health technologies. Many health outcomes are affected by poor medication adherence, ill-advised health behaviors, and poor access to medical care. The candidate’s career goal is to conquer these barriers by harnessing the potential of current (e.g., mobile) and future technologies as tools to fulfill these endeavors. Functional abdominal pain disorders (FAPDs) affect up to 15% of school- age children (and adults) worldwide and are associated with significant morbidity and healthcare costs. Up to 60% of children with FAPDs go on to have similar conditions as adults. Many affected children suffer from psychosocial distress like anxiety and depression. The most effective treatment for these disorders (psychological interventions) remains out of reach for most children with FAPDs. The applicant proposes to refine his innovative mobile application (App) prototype designed to remotely deliver audio-recorded guided imagery therapy (ARGIT App) for pediatric patients with FAPDs using accepted technology development techniques. The applicant has employed a user-centered design approach with patients and providers to develop a refined ARGIT App (Specific Aim 1). This extension will focus on the grant’s final two Specific Aims: 2) Conduct a randomized, waitlist-controlled trial comparing treatment with guided imagery therapy (GIT) versus usual care in children with FAPDs. The GIT sessions will be delivered remotely via the refined ARGIT App over eight weeks. 3) Assess the acceptability of the refined ARGIT App among affected children and their caregivers through qualitative interviews. Dr. Hollier has assembled a multidisciplinary team of esteemed NIH-funded mentors and collaborators with diverse expertise in mobile health App development, clinical trial methodology, qualitative research methods, and health behavior change specialists. In addition, the candidate will acquire additional training through workshops and conferences to increase his knowledge base of chronic pain, community-based participatory research, non-pharmacological technology-based therapeutics for pain, and professional development supporting grant writing and research team management. The scientific training and educational opportunities afforded by this grant will lead to publications, scientific data, and experience that will enhance the candidate’s fund of knowledge for securing independent NIH funding as a physician-scientist specializing in health technologies.