Forging Ahead: Deep South Center to Reduce Disparities in Chronic Diseases

项目摘要/摘要 “南方腹地”，包括阿拉巴马州、密西西比州和路易斯安那州，肥胖率、糖尿病患病率最高， 以及全国范围内的高血压。因此，南方腹地的预期寿命大大低于其他地区 地区，这种差异对美国黑人来说甚至更大。深南中心的使命是 减少慢性病差距(P50MD017338)就是促进健康公平，减轻负担 心脏代谢性疾病横跨整个南方腹地。该中心专注于预防、治疗和 美国黑人和低收入人群心脏代谢性疾病的管理 与我们三州地区的这些条件不成比例。该中心通过以下方式进行主题统一 在整个保健连续体中应用精确的公共卫生办法，以实现卫生公平， 定义为“在正确的时间向正确的人群提供正确的干预”。这种方法 认识到环境、文化、个人信仰和偏好的重要性，以及 多层次、多领域干预。该中心汇聚了一支跨学科的团队 来自3个相邻州的4个机构的调查人员(阿拉巴马大学伯明翰分校，塔斯基吉 路易斯安那州彭宁顿生物医学研究中心和密西西比医学大学 中心)以及地区性非学术合作伙伴将心脏代谢研究扩展到现实世界 社区和临床环境。为了完成其使命，该中心目前包括3个核心 (管理核心、调查员开发核心和社区参与核心)和3 R01级 研究项目，所有项目都侧重于以社区或诊所为基础的心脏代谢性疾病干预 在整个护理过程中。这一竞争性修订建立在中心目前扩大其覆盖范围的工作基础上 增加了四个相互关联的试点干预试验，评估新的治疗干预措施 美国黑人心脏代谢性疾病的预防和管理。这些项目由 四名富有成效和有前途的初级调查人员致力于卫生公平研究，这进一步支持 该中心的目标是增加该地区卫生公平研究人员的数量。考虑到重要的 心脏代谢性疾病的健康差距在南方腹地很明显，再加上基础设施和 中心为这些新调查人员提供的合作，这一竞争性修订将进一步扩大 这些区域努力改善心脏代谢结果的健康公平性的影响。

PROJECT SUMMARY/ABSTRACT The “Deep South,” including Alabama, Mississippi, and Louisiana, has the highest rates of obesity, diabetes, and hypertension in the nation. As a result, life expectancy in the Deep South is substantially lower than other regions, and this discrepancy is even greater for Black Americans. The mission of the Deep South Center to Reduce Disparities in Chronic Diseases (P50MD017338) is to promote health equity and reduce the burden of cardiometabolic diseases across the Deep South. The Center focuses on the prevention, treatment, and management of cardiometabolic diseases among Black Americans and low-income populations who suffer disproportionately from these conditions in our tri-state region. The Center is unified thematically through the application of the precision public health approach across the care continuum to achieve health equity, defined as “providing the right intervention to the right population at the right time”. This approach acknowledges the importance of context, culture, individual beliefs, and preferences as well as the need for multi-level and multi-domain interventions. The Center brings together a trans-disciplinary team of investigators from 4 institutions in 3 contiguous states (the University of Alabama at Birmingham, Tuskegee University, Louisiana’s Pennington Biomedical Research Center, and the University of Mississippi Medical Center) as well as regional non-academic partners to extend cardiometabolic research into real-world community and clinical settings. To accomplish its mission, the Center currently includes 3 cores (Administrative Core, Investigator Development Core, and Community Engagement Core) and 3 R01-level research projects, all of which focus on community- or clinic-based interventions for cardiometabolic diseases across the care continuum. This competitive revision builds on the Center’s current work to expand its reach with the addition of four interrelated pilot intervention trials evaluating novel therapeutic interventions for the prevention and management of cardiometabolic diseases among Black Americans. These projects are led by four productive and promising junior investigators committed to health equity research, which further supports the Center’s objectives to grow the number of health equity researchers in the region. Given the significant health disparities in cardiometabolic diseases evident in the Deep South coupled with the infrastructure and collaborations provided by the Center for these new investigators, this competitive revision will further expand the impact of these regional efforts to improve health equity for cardiometabolic outcomes.