INCIDENCE OF HIV INFECTIONS IN A COHORT OF IV DRUG USERS

描述：（申请人摘要） 本研究的目的是确定时间趋势和风险因素 目前艾滋病毒呈阴性的注射毒品使用者中新的艾滋病毒感染 但仍处于高风险状态 这将通过跟踪1，000人的队列来完成 艾滋病毒阴性吸毒者，每隔6个月进行一次，为期3年。 本研究将 允许评估与行为改变相关的因素， 在这个高危人群中。 它还将允许对 药物治疗、针头注射等干预措施的实地效果 交换、针头消毒和教育方案，以减少高风险 行为，以防止艾滋病毒感染的人口吸毒者， 巴尔的摩，目前艾滋病毒感染的年发病率为4%。 在 此外，还将评估这一人群的发病率和死亡率， 并与在同一时间跟踪的艾滋病毒阳性人群进行比较， 诊所 这将有助于评估该人群中的哪些疾病 与艾滋病有关。 艾滋病毒和其他常见感染之间的相互作用 这个队列，如B肝炎和丙型肝炎，结核病，HTLV-II和 将评估肺炎球菌。 这项研究将有助于确定 艾滋病毒血清转换者在感染后不久。 详细病毒学 最近的HIV血清转换者的免疫学研究将允许 更好地了解艾滋病毒感染的早期自然史， 为了设计干预战略， 发展到艾滋病。 美国吸毒者中艾滋病病例的比例及其 儿童和性接触正在增加。 控制艾滋病流行 美国需要更好地了解目前的发病率， 和艾滋病毒感染的危险因素。

DESCRIPTION: (Applicant's Abstract) The purposes of this study are to identify temporal trends and risk factors for new HIV infection in injecting drug users who are currently HIV negative but remain at high risk. This will be done by following a cohort of 1,000 HIV negative drug users at six month intervals for 3 years. This study will allow the evaluation of the factors associated with behavior change over time in this high risk population. It will also allow an evaluation of the field effectiveness of such interventions as drug treatment, needle exchange, needle disinfection and educational programs to reduce high risk behavior in order to prevent HIV infection in a population of drug users in Baltimore, who currently have a 4% annual incidence of HIV infection. In addition, morbidity and mortality rates in this population will be assessed and compared with an HIV-positive population being followed in the same clinic. This will allow evaluation of which illnesses in this population are HIV-related. The interaction between HIV and other common infections in this cohort, such as hepatitis B and C, tuberculosis, HTLV-II and pneumococci will be evaluated. This study will allow the identification of HIV seroconverters soon after they become infected. Detailed virological and immunological studies among recent HIV seroconverters will allow a better understanding of the early natural history of HIV infections in this population, in order to design intervention strategies to prevent rapid progression to AIDS. The proportion of AIDS cases in the United States among drug users and their children and sexual contacts is increasing. Control of the AIDS epidemic in the United States requires a better understanding of the current incidence and risk factors for HIV infection in this critical population.