AUTOMATED INTERPRETATION OF PROTON MAGNETIC RESONANCE

核磁共振波谱(MRS)提供了独特的化学物质 数据，补充由Magic提供的解剖信息 磁共振成像(MRI)为活体成像增加了一个新的维度 神经疾病的诊断。夫人现在正在从 实验室和探索性临床研究显示了广泛的 可能的临床应用，从危重新生儿 到老年痴呆症。它在临床上的广泛应用 重要的新诊断将需要快速和可靠的开发 根据代谢物解释光谱的自动化工具 浓度和医学诊断。ORINCON建议开发MRS 基于神经网络模型的解释软件 单一代谢物的光谱数据库。在这个项目的第一阶段， ORINCON将设计和实施原型软件，以估计 大脑的模拟一维质子光谱， 对诊断有重要意义的化合物的浓度 神经紊乱。最终目标，将在第二阶段实现 这个程序，是为了实现MRS分析软件， 在没有操作员干预的情况下，解释大脑MRS数据 代谢物浓度术语和相关的概率 疾病。口译软件将与目前兼容 二手光谱包，也将是便携式的个人 计算机(PC)平台。 建议的商业应用： 用于自动分析大脑核磁共振谱的软件将是一个 商业上可行的产品，可以作为 现有的MRS套餐。我们预计口译软件 将在开发的MRS软件包SageIDL内实施 GE医疗系统公司的核磁共振成像(MRI) 扫描仪。这里开发的方法也可能会发现商业 尿磁共振波谱在医疗诊断工具中的应用， 脑脊液、血浆、胆汁、精液和羊水，以及 在原子和分子光谱学中。

Nuclear Magnetic Resonance Spectroscopy (MRS) offers unique chemical data, complementary to the anatomic information provided by the Magnetic Resonance Imaging (MRI), that adds a new dimension to the in vivo diagnosis of neurological disease. MRS is now emerging from the laboratory and exploratory clinical studies that have shown a wide range of possible clinical applications, ranging from critically ill neonates to dementia in the elderly. The widespread clinical application of this important new diagnostic will require development of fast and reliable automated tools for interpretation of the spectra in terms of metabolite concentrations and medical diagnosis. ORINCON proposes to develop MRS interpretation software based on a neural network model employing a database of spectra of single metabolites. In Phase I of this project, ORINCON will design and implement prototype software to estimate, from simulated, one-dimensional proton spectra of the brain, the concentrations of compounds that are important for diagnosis of neurological disorders. The ultimate goal, to be realized in Phase II of this program, is to implement the MRS analysis software that will, without intervention of the operator, interpret the brain MRS data in terms of the metabolite concentrations and probability of relevant diseases. The interpretation software will be compatible with presently used spectroscopy packages and will also be portable to a personal computer (PC) platform. PROPOSED COMMERCIAL APPLICATION: Software for automated analysis of NMR spectra of the brain will be a commercially viable product that can be distributed as a part of existing MRS packages. We anticipate that the interpretation software will be implemented within SageIDL - the MRS software package developed by GE Medical Systems for nuclear magnetic resonance image (MRI) scanners. The methods developed here may also find commercial application in medical diagnostic tools based on MRS of urine, cerebrospinal fluid, plasma, bile, semen, and amniotic fluid, as well as in atomic and molecular spectroscopy.