ENDOCRINE DISRUPTORS AND HUMAN GENDER DEVELOPMENT

宫内和哺乳期接触铅对工人影响的研究 调节激素的污染物在很大程度上仅限于对 认知发展。这些调查的结果变量是 没有被选中对潜在的性激素调节敏感 这些物质的影响。拟议的流行病学研究评估 早期发育暴露于环境中的行为后遗症 毒物对表现出性别相关变化的人类行为的影响。这个 研究设计利用了已建立的受试者队列(纽约州 钓鱼者队列研究)收集以评估 短期和长期食用受污染的运动鱼 对成年人及其后代的健康影响。生殖结局数据 包括对母亲住院分娩记录的详细摘要 谁食用了不同数量的受污染的鱼 在1986-91年间出生的3,365名子女。大多数孩子都是 现在接近童年中期，使他们足够大到可以评估 广泛的行为后遗症。这项研究将以下列方式进行 由父母/监护人担任调查对象的邮寄问卷调查 孩子行为的告密者。目标为的行为域 研究是那些在正常情况下表现出性别相关变异的研究 具体情况，包括儿童时期的性别角色行为 学习障碍、利手和精神病理模式 症状。关于母体接触受污染鱼类的信息，长期- 孕期和孕期可用于评估剂量反应效应。 这项拟议的问卷调查代表了 涉及深入发展调查的长期研究计划 包括神经心理评估、结构化临床 采访，以及更深入的曝光表征 后代。这种深入的后续调查将包括 研究方法足以同时评估生物学和 行为后遗症的社会环境解释。整体而言 该试点项目的目标是评估 选定的毒物暴露(出生前和出生后)和行为结果 因为他们容易受到性激素生理的干扰 在性别分化过程的敏感期和在 对母体无毒的浓度。

Studies on the influence of in utero and lactational exposure to hormone-modulating pollutants have largely been restricted to studies of cognitive development. Outcome variables in these investigations were not selected to be sensitive to the potential sex hormone-modulating effects of these substances. The proposed epidemiologic study assesses the behavioral sequelae of early developmental exposure to environmental toxicants on human behaviors that exhibit gender-related variation. The study design utilizes an established cohort of subjects (New York State Angler Cohort Study) assembled to assess the association between consumption of contaminated sport fish on both short- and long-term health effects in adults and their offspring. Reproductive outcome data including detailed abstraction of hospital delivery records for mothers who had consumed varying quantities of contaminated fish are available for 3,365 offspring born between 1986-91. The majority of children are now approaching middle childhood, making them old enough to assess a broad spectrum of behavioral sequelae. The study is to be conducted as a postal questionnaire survey in which a parent/guardian serves as an informant of the child's behavior. The behavioral domains targeted for study are those which exhibit gender related variation under normal circumstances, including gender-role behavior of childhood, specific learning disabilities, handedness, and patterns of psychopathologic symptoms. Information on maternal exposure of contaminated fish, long- term and during pregnancy is available to assess dose-response effects. This proposed questionnaire survey represents the initial stage of a long-term research plan involving in-depth developmental investigations including neuropsychological assessments, structured clinical interviews, and more in-depth exposure characterization of the offspring. Such an in-depth follow-up investigation will incorporate research methods adequate to simultaneously evaluate both biological and social-environmental explanations of behavioral sequelae. The overall goal of this pilot project is to assess the relationship between toxicant exposures (pre-and postnatal) and behavioral outcomes selected because they are susceptible to perturbation of sex hormone physiology at sensitive periods of the sexual differentiation process and at concentrations that are not maternally toxic.