Mechanisms of Cell Death Driven Inflammation in the Skin

炎症性皮肤状况是疾病的主要原因。目前的治疗方法治疗的是症状，而不是炎症的原因。皮肤细胞不断地与免疫系统细胞相互作用，并与各种有益和有害的微生物相互作用。我的数据表明，皮肤菌群和常驻免疫细胞在皮肤病的发生和发展中的作用。我将研究微生物群和免疫细胞如何在皮肤中启动细胞死亡和驱动过度的免疫反应。

Inflammatory skin conditions are a leading cause of disease. Current therapies treat symptoms not causes of inflammation. Skin cells constantly interact with cells of the immune system, and with a diverse array of helpful and harmful microorganisms. My data suggest a role of the skin flora and resident immune cells in the initiation and progression of skin disease. I will investigate how the microbiota and immune cells can initiate cell death and drive excessive immune responses in the skin.