MATCHING PATIENTS TO ALCOHOLISM TREATMENTS

申请者摘要：这项研究的总体目标是测试 “匹配假说”，即酒精治疗的有效性可以 通过将具有某些特征的客户端分配给 特殊的治疗。本申请提议继续开展工作 在过去五年中发起和实施的。的具体目标 研究内容为：检验主次先验匹配 在15个月的跟踪过程中提出的假设；进行 心理测量学和其他对患者、治疗过程和 检验这些匹配假设的结果变量；检验 用于测试匹配的替代分析策略和变量；以及 以确定匹配效果在三个月内持续的程度 治疗结束后的一年内。 从项目匹配门诊收集的数据集(N=954)和 后续服务(N=774)试验的ARM将被分析以实现以下目标 目标。受试者被随机分配到三种治疗方法中的一种，12种 STEP、认知行为或动机增强。它们是 在治疗前对基线和匹配变量进行评估 从治疗分配开始，每隔3个月随访15个月 以衡量他们的酒精摄入量和其他方面的结果。 为了测试长期配对效果，客户在门诊部 这项研究将在治疗后39个月进行联系和评估 入会仪式。 预计研究结果将对酒精治疗产生影响 未来十年的研究和交付。 项目比赛指导委员会，在与NIAAA讨论后 工作人员已选择提交跨每个CRU的通用提案， 反映了共同议定书和指导的合作进程 该项目在其运营的头五年中一直在进行。但是，每个CRU 在预算中提供了具体地点的信息，预算 理由、关键人员名单、咨询/联合体 协议，以及各自提案中的人类主体部分。

APPLICANT'S ABSTRACT: The overall aim of this study is to test the "matching hypothesis" that alcohol treatment effectiveness can be increased by assigning clients with certain characteristics to particular treatments. The present application proposes to continue work initiated and conducted over the past five years. The specific aims of the study are: to test primary and secondary a priori matching hypotheses over the course of 15 months of follow-up; to conduct psychometric and other analyses of patient, treatment process, and outcome variables to test these matching hypotheses; to examine alternative analytic strategies and variables for testing matching; and to determine the extent to which matching effects persist over a three year period following treatment completion. Data sets collected form the Project MATCH outpatient (N=954) and aftercare (N=774) arm of the trial will be analyzed top achieve these aims. Clients were randomly assigned to one of three treatments, Twelve Step, Cognitive Behavioral, or Motivational Enhancement. They were assessed prior to treatment on baseline and matching variables and followed, at 3 month intervals, for 15 months from treatment assignment to measure their alcohol consumption and other dimensions of outcome. To test longer term matching effects clients in the outpatient arm of the study will be contacted and assessed at 39 months after treatment initiation. It is anticipated that study results will impact on alcohol treatment research and delivery for the next decade. The Project MATCH Steering Committee, following discussion with NIAAA Staff, has chosen to submit a generic proposal across each of the CRUs, reflecting the common protocol and cooperative process that has guided the project across its first five years of operation. However, each CRU has provided site-specific information in the budget, budget justification, listing of key personnel, consultation/consortium agreements, and human subjects sections of their respective proposals.